Angiogenesis

1. Front Matter

   Pages i-x

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2. Introductory Comments

   1. Introductory Comments

      • Michael E. Maragoudakis

      Pages 1-4

3. Models and Methods for Assessing Angiogenesis

   1. Front Matter

      Pages 5-5

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   2. Microvascular Endothelial Cells from Adrenal Medulla — A Model for in Vitro Angiogenesis

      • Dipak K. Banerjee, Juan A. Martínez

      Pages 7-18

   3. Angiogenesis in the Heart and Skeletal Muscle — Models for Capillary Growth

      • O. Hudlicka, S. Egginton, M. D. Brown

      Pages 19-33

   4. Basement Membrane Biosynthesis as a Biochemical Index of Angiogenesis in Chick Chorioallantoic Membrane

      • Nikos E. Tsopanoglou, Michael E. Maragoudakis

      Pages 35-38

   5. The Rat and the Rabbit Cornea Assay

      • Lucia Morbidelli, Marina Ziche

      Pages 39-46

   6. The Rat Aorta Model of Angiogenesis: Methodology and Applications

      • Roberto F. Nicosia

      Pages 47-53

   7. Assessment of Angiogenesis by MRI

      • Michal Neeman

      Pages 55-60

   8. Measuring Intratumoral Microvessel Density

      • Noel Weidner

      Pages 61-74

   9. Patterns of Physiological Angiogenesis in Adult Mesentery

      • F. Hansen-Smith, Laura Morris

      Pages 75-84

   10. Angiogenesis — Critical Assessment of in-Vitro Assays and in — Vivo Models

       • David BenEzra

       Pages 85-89

4. Angiogenic Factors and Their Receptors

   1. Front Matter

      Pages 91-91

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   2. The Several Roles for Oxygen in Wound Angiogenesis

      • Jeffrey J. Gibson, Thomas K. Hunt, John J. Feng, Mark D. Rollins, Ahmad Y. Sheikh, M. Zamirul Hussain

      Pages 93-98

   3. Autocrine Role of Basic Fibroblast Growth Factor (bFGF) in Angiogenesis and Angioproliferative Diseases

      • Anna Gualandris, Patrizia Dell’Era, Marco Rusnati, Roberta Giuliani, Elena Tanghetti, Maria Pia Molinari-Tosatti et al.

      Pages 99-112

   4. Inflammatory Angiogenic Factors in a Model of Chronic Inflammation

      • James D. Winkler, Michael P. Seed, Jeffrey R. Jackson

      Pages 113-120

   5. Angiogenic Mediators in Wound Healing

      • Luisa A. DiPietro, Nicholas N. Nissen

      Pages 121-128

   6. Modulation of Vascular Endothelial Growth Factor Angiogenic Activity by ADP-Ribosylation

      • John J. Feng, Q. Perveen Ghani, Gabriel Ledger, Rahmat Barkhordar, Thomas K. Hunt, M. Zamirul Hussain

      Pages 129-135

   7. Role of Fibroblast Growth Factor -2 and Endothelial Cell Stimulating Angiogenic Factor (ESAF) in Capillary Growth in Skeletal Muscles Exposed to Long-Term High Activity

      • M. D. Brown, H. Walter, O. Hudlicka, F. M. Hansen-Smith, J. B. Weiss

      Pages 137-147

   8. Angiogenesis in Atherosclerosis: Possible Roles for Vascular Endothelial Cell Growth Factor, Endothelial Cell Stimulating Angiogenesis Factor and Soluble E-Selectin

      • J. B. Weiss, A. Blann, Jun-Ling Li, C. N. McCollom, A. Bate

      Pages 149-155

Interest in angiogenesis research remains strong in recent years and exciting new discoveries, about modulators of angiogenesis, their receptors, the transduction mechanisms and the angiogenic genes involved, have contributed to our present day understanding of this complex process. This knowledge has provided the basis and broadened the scope of angiogenesis - based therapy in oncology and many other clinical conditions. This monograph contains the contributions to the NATO Advanced Study Institute on "Angiogenesis: Models, Modulators and Clinical Applications", which was held in Rhodes, Greece, from June 20-30, 1997. This was the fourth of a series of NATO supported international meetings on Angiogenesis aiming to bring together basic scientists with clinicians to exchange ideas, disseminate new knowledge and discuss the present status and potential new directions in this fast moving area of biomedical research. The International Organising Committee that included Drs. E. Dejana, C Haudenschild, M. Hackel, H. Kleinman, P. Lelkes, M. Presta, P. Polverini, D. Thompson, has provided invaluable help with their insightful suggestions in the formulation of the scientific program for which I am grateful. I wish to thank all the participants for their enthusiastic participation and their complimentary comments on the success of the conference.

• angiogenesis
• cancer
• cell
• endothelium
• pathology
• research
• skeletal muscle
• tumor

• University of Patras Medical School, Patras, Greece

  Michael E. Maragoudakis

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