Progress in Alzheimer’s and Parkinson’s Diseases

1. Front Matter

   Pages i-xxiii

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2. Pathology in Alzheimer’s Disease: General

   1. The Pathogenesis of Alzheimer’s Disease

      • Robert D. Terry

      Pages 1-5

   2. Molecular and Cellular Abnormalities of Tau in Early Alzheimer’s Disease

      • Peter Davies, Charles Weaver, Gregory A. Jicha

      Pages 7-11

3. Apolipoprotein E

   1. Apoe and Memory in Alzheimer’s Disease

      • Hilkka S. Soininen, Paavo J. Riekkinen Sr.

      Pages 13-16

   2. Divergent Metabolism of Apolipoproteins E3 and E4 by Cells

      • Robert E. Pitas, Zhong-Sheng Ji, Lubica Supekova, Robert W. Mahley

      Pages 17-23

   3. App, Apoe, and Presenilin Transgenics

      • L. Pradier, C. Czech, L. Mercken, S. Moussaoui, M. Reibaud, P. Delaère et al.

      Pages 25-30

   4. Differential Susceptibility of Human Apolipoprotein E Isoforms to Oxidation and Consequences on their Interaction with Phospholipids

      • Corinne Jolivalt, Brigitte Leininger-Muller, Philippe Bertrand, Gérard Siest

      Pages 31-38

   5. The Apolipoprotein E ε4 Allele

      • A. S. Rigaud, L. Traykov, L. Caputo, J. de Rotrou, F. Moulin, R. Couderc et al.

      Pages 39-43

4. Apoptosis; Oxidative Stress; Amyloids, Inflammation, and Other Defects

   1. Apoptosis in Alzheimer’s Disease

      • Carl W. Cotman, Christian J. Pike

      Pages 45-51

   2. Membrane Constituencies and Receptor Subtype Contribute to Age-Related Increases in Vulnerability to Oxidative Stress

      • J. A. Joseph, N. Denisova, D. Fisher, I. Cantuti-Castelvetri, S. Erat

      Pages 53-58

   3. Mitochondrial Dysfunction and Alzheimer’s Disease

      • Soumitra S. Ghosh, Scott Miller, Corinna Herrnstadt, Eoin Fahy, Leslie A. Shinobu, Douglas Galasko et al.

      Pages 59-66

   4. Mitochondrial Dysfunction in Parkinson’s Disease

      • Russell H. Swerdlow, Janice K. Parks, Scott W. Miller, John N. Davis II, Patricia A. Trimmer, Jeremy B. Tuttle et al.

      Pages 67-75

   5. Neuronal Oxidative Stress is a Common Feature of Alzheimer’s and Parkinson’s Diseases

      • George Perry, Mark A. Smith

      Pages 77-80

   6. Common Mechanisms in Cell Cycle and Cell Death

      • D. Uberti, M. Belloni, C. Rizzini, A. Fontanini, L. Piccioni, M. Grilli et al.

      Pages 81-87

   7. Intracerebroventricular Administration of Beta-Amyloid Peptide (25-35) Induces Oxidative Stress and Neurodegeneration in Rat Brain

      • Natalia V. Gulyaeva, Ilya V. Victorov, Mikhail Yu. Stepanichev, Mikhail V. Onufriev, Olga S. Mitrokhina, Yulia V. Moiseeva et al.

      Pages 89-98

   8. Molecular Characterization of the Neuroprotective Activity of Salicylates

      • M. Grilli, M. Pizzi, F. Goffi, M. Benarese, G. M. Gerardi, M. Memo et al.

      Pages 99-103

   9. N-Methyl(R)Salsolinol: A Neurotoxin Candidate to Induce Parkinson’s Disease Causes Apoptosis in Dopamine Cells

      • Wakako Maruyama, Makoto Naoi

      Pages 105-111

   10. Age-Related Na,K-Atpase mRNA Expression and Alzheimer’s Disease

       • George J. Siegel, Neelima B. Chauhan, John M. Lee

       Pages 113-119

   11. HB-GAM, a Novel Amyloid Associated Protein, is Present in Prion Related Disorders and other Cerebral Amyloidoses

       • Maciej M. Lalowski, Marc Baumann, Heikki Rauvala, Blas Frangione, Thomas Wisniewski

       Pages 121-131

   12. Regulation of APP Metabolism by Protein Phosphorylation

       • J. D. Buxbaum, A. Ikin, Y. Luo, J. Naslund, S. Sabo, B. Vincent et al.

       Pages 133-140

This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro­ gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus­ pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca­ demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop­ ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus­ sion. There were 122 talks and 161 posters. This book incorporates a combination of both.

• Alzheimer
• Parkinson
• dopamine
• neurons
• transplantation

• Israel Institute for Biological Research, Ness Ziona, Israel

  Abraham Fisher

• Loyola University of Chicago, Maywood, USA

  Israel Hanin

• Jichi Medical School, Tochigi, Japan

  Mitsuo Yoshida

Policies and ethics