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  • © 2002

Rational Design of Stable Protein Formulations

Theory and Practice

Part of the book series: Pharmaceutical Biotechnology (PBIO, volume 13)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xvii
  2. Practical Approaches to Protein Formulation Development

    • Byeong S. Chang, Susan Hershenson
    Pages 1-25
  3. Recombinant Production of Native Proteins from Escherichia coli

    • Tsutomu Arakawa, Tiansheng Li, Linda O. Narhi
    Pages 27-60
  4. Physical Stabilization of Proteins in Aqueous Solution

    • Brent S. Kendrick, Tiansheng Li, Byeong S. Chang
    Pages 61-84
  5. Rational Design of Stable Lyophilized Protein Formulations: Theory and Practice

    • John F. Carpenter, Beyong S. Chang, William Garzon-Rodriguez, Theodore W. Randolph
    Pages 109-133
  6. Spray-Drying of Proteins

    • Geoffrey Lee
    Pages 135-158
  7. Surfactant-Protein Interactions

    • Theodore W. Randolph, LaToya S. Jones
    Pages 159-175
  8. Back Matter

    Pages 199-206

About this book

Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view.

This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.

Editors and Affiliations

  • University of Colorado Health Sciences Center, Denver, USA

    John F. Carpenter, Mark C. Manning

Bibliographic Information

  • Book Title: Rational Design of Stable Protein Formulations

  • Book Subtitle: Theory and Practice

  • Editors: John F. Carpenter, Mark C. Manning

  • Series Title: Pharmaceutical Biotechnology

  • DOI: https://doi.org/10.1007/978-1-4615-0557-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2002

  • Hardcover ISBN: 978-0-306-46741-7Published: 30 April 2002

  • Softcover ISBN: 978-1-4613-5131-3Published: 30 October 2012

  • eBook ISBN: 978-1-4615-0557-0Published: 06 December 2012

  • Series ISSN: 1078-0467

  • Edition Number: 1

  • Number of Pages: XVII, 206

  • Topics: Pharmacology/Toxicology, Pharmacy, Biochemistry, general, Biotechnology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access