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Foundations of Pharmacokinetics

  • Book
  • © 2003

Overview

Authors:
  1. Aldo Rescigno

    1. University of Minnesota, Minneapolis

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Introduction

    Pages 1-3

  3. Models

    Pages 5-15

  4. Physical Quantities

    Pages 17-26

  5. The Birth of Compartments

    Pages 27-35

  6. Linear Differential Equations

    Pages 37-50

  7. Stochastic Compartments

    Pages 51-59

  8. Directed Graphs

    Pages 61-68

  9. Linear Graphs

    Pages 69-82

  10. Moments

    Pages 83-93

  11. Integral Equations

    Pages 95-111

  12. Matrix Equations

    Pages 113-125

  13. Non-Linear Models

    Pages 127-134

  14. Clearance

    Pages 135-141

  15. Turnover

    Pages 143-147

  16. Volume and Dilution Factor

    Pages 149-159

  17. Time Parameters

    Pages 161-170

  18. Bioavailability and Bioequivalence

    Pages 171-177

  19. Conclusion

    Pages 179-180

  20. Back Matter

    Pages 181-228
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Keywords

About this book

This book has its origin in my experience as a teacher of pharmacokinetics in many universities in four different continents. It was not my intention to write a popular book; what distinguishes this one from many others on the same subject is its large use of algebra and calculus. For this I make no apologies; in fact a serious study of pharmacokinetics without the help of mathematics is, in my opinion, impossible. The exact definition of many pharmacokinetic quantities, even the most common, and the correct use of many equations, even the most simple, requires the constant use of mathematical language. On the other hand I have made a considerable effort to use only elementary algebra and elementary calculus, as commonly taught in most introductory university courses. For the few exceptions, when less common mathematical concepts were needed, I have supplied the necessary explanations in four appendices. The first three chapters are a general introduction to the scientific method. Chapters 4 to 12 show different specific methods to deal with pharmacokinetic pr- lems. There is considerable overlap among those chapters; this is intentional and its p- pose is to convince the reader that every problem can be solved in more than one way, including ways that were not mentioned in this book and that intelligent readers can find for their own pleasure. Chapters 13 to 17 show how different parameters of importance in pharmacokinetics can be exactly defined and measured.

Authors and Affiliations

  • University of Minnesota, Minneapolis

    Aldo Rescigno

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