Calcium Channel Pharmacology

Editors: McDonough, Stefan I. (Ed.)

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About this book

Voltage-gated calcium channels are critical regulators of cytoplasmic levels of calcium, the universal signaling ion. As such, calcium channels trigger a wide range of cellular functions, from muscle contraction to neurotransmitter secretion, and are important players in human disease. Prominent in the nervous, cardiovascular, and endocrine systems, members of the calcium channel family are targets for existing antihypertensive and anticonvulsant drugs. In addition, they are emerging targets for drugs to treat an extraordinarily diverse group of disorders, including pain, cerebral ischemia, cardiac arrhythmia, and migraine. This book reviews the compounds that target individual calcium channel subtypes and the cellular and behavioral functions governed by each different channel. It contains information for basic scientists using calcium channel antagonists as experimental tools, for behavioralists studying animal models of human disease, and for pharmaceutical scientists interested in creating the next generation of calcium channel-targeted drugs. Several factors make an entire book on calcium channel pharmacology timely.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Concepts of State-Dependent Pharmacology of Calcium Channels

    Pages 1-19

    Timin, Evgeni N. (et al.)

  • Pharmacology of Cav1 (L-Type) Channels

    Pages 21-72

    Triggle, David J.

  • The Therapeutic Utility of Targeting Cav2 Channels

    Pages 73-93

    Cohen, Charles J. (et al.)

  • Peptide Toxin Inhibition of Voltage Gated Calcium Channels

    Pages 95-142

    McDonough, Stefan I.

  • Calcium Channel Blocking Polypeptides

    Pages 143-181

    Norton, Raymond S. (et al.)

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Bibliographic Information

Bibliographic Information
Book Title
Calcium Channel Pharmacology
Editors
  • Stefan I. McDonough
Copyright
2004
Publisher
Springer US
Copyright Holder
Kluwer Academic/Plenum Publishers, New York
eBook ISBN
978-1-4419-9254-3
DOI
10.1007/978-1-4419-9254-3
Hardcover ISBN
978-0-306-47878-9
Softcover ISBN
978-1-4613-4860-3
Edition Number
1
Number of Pages
XV, 418
Topics