Emerging Targets in Antibacterial and Antifungal Chemotherapy

1. Front Matter

   Pages i-xv

   PDF

2. Antibacterial Chemotherapy

   1. Front Matter

      Pages N1-N1

      PDF

   2. Historical Perspectives of Approaches to Antibiotics Discovery

      • Akira Imada, Kunimoto Hotta

      Pages 1-23

   3. Bacterial Pathogens for the 1990s: A Case for New Drug Development

      • George L. Drusano

      Pages 24-36

   4. DNA Replication

      • Charles S. McHenry

      Pages 37-67

   5. RNA Synthesis in Bacteria: Mechanism and Regulation of Discrete Biochemical Events at Initiation and Termination

      • Asis Das, Joseph DeVito, Jason Sparkowski, Frederick Warren

      Pages 68-116

   6. Bacterial Cell Division

      • Joe Lutkenhaus

      Pages 117-150

   7. Fatty Acid Biosynthesis

      • Suzanne Jackowski

      Pages 151-162

   8. Protein secretion in bacteria: a chemotherapeutic target?

      • Rajeev Misra, Thomas J. Silhavy

      Pages 163-175

   9. Cytosolic Enzymes in Peptidoglycan Biosynthesis as Potential Antibacterial Targets

      • W. Stephen Faraci

      Pages 176-204

   10. Strategies in β-lactam Design

       • Francis C. Neuhaus, Nafsika Georgopapadakou

       Pages 205-273

   11. Lipid A Biosynthesis

       • Jack Coleman

       Pages 274-291

   12. Compromising the Protective Barrier of the Gram-Negative Bacterial Cell Surface

       • Catherine P. Reese, Joanna Clancy

       Pages 292-322

   13. Bacterial Virulence Factors as Targets for Chemotherapy

       • Sarah K. Highlander, George M. Weinstock

       Pages 323-346

3. Antifungal Chemotherapy

   1. Front Matter

      Pages 347-347

      PDF

   2. Invasive Fungal Infections: Problems and Challenges for Developing New Antifungal Compounds

      • Thomas J. Walsh

      Pages 349-373

   3. Topoisomerase II Inhibitors: Prospects for New Antifungal Agents

      • David E. Jackson, D. P. Figgitt, Stephen P. Denyer

      Pages 374-392

   4. Functions for Sterols in Yeast Membranes

      • Leo W. Parks, R. Todd Lorenz, Warren M. Casey

      Pages 393-409

   5. Biochemical Aspects of Ergosterol Biosynthesis Inhibition

      • Keith Barrett-Bee, Neil Ryder

      Pages 410-436

   6. Rationally Designed Inhibitors of Sterol Biosynthesis

      • A. C. Oehlschlager, Eva Czyzewska

      Pages 437-475

Emerging Targets in Antibacterial and Antifungal Chemotherapy offers constructive ideas to researchers that could lead to the discovery of entirely new classes of drugs. The authors emphasize new topics rather than review work on known antibacterials and antifungals, and identify new targets--either the rate-limiting component of a biochemical pathway or a component of the pathway that is susceptible to a ``screening'' or ``rational drug design'' approach. Each chapter reviews the biochemical pathway and its place in the cellular scheme in order to place the target in perspective. The authors, a mixture of academic researchers and drug-discovery investigators in pharmaceutical companies, also extend these theoretical concerns into practical applications and suggest useful screening methodologies. The importance of this subject area is demonstrated by the increasing number of papers in the literature that point to potential targets and screening methodologies for new antibacterials. This book also deals with antifungals, investigating the inherent limitations in existing antifungals (many of which are extremely toxic or have only limited efficacy), and pointing to major developments in the discovery of novel antifungals. Emerging Targets in Antibacterial and Antifungal Chemotherapy will be of interest to professional microbiologists, biochemists, and cell biologists in both academic and industrial laboratories.

• DNA
• Lipid
• RNA
• enzymes
• lead
• proteins

This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School; This is a book which will be invaluable to a variety of physicians and basic scientists working in the field of antimicrobial chemotherapy. - R C Moellering, Physician-in-Chief, Harvard Medical School

• Department of Chemotherapy (58/2), Roche Research Center, Nutley, USA

  Nafsika H. Georgopapadakou

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