The Importance of Animal Experimentation for Safety and Biomedical Research

1. Front Matter

   Pages i-vii

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2. The necessity of animal experimentation

   1. The necessity of animal experimentation

      • Silvio Garattini

      Pages 1-3

3. Ethical and Legal Aspects

   1. Front Matter

      Pages 5-5

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   2. Animal experimentation defended

      • Carl Cohen

      Pages 7-16

   3. The ethics of animal use in biomedicine

      • T. L. S. Sprigge

      Pages 17-28

   4. Legal and political problems of animal experimentation the ‘Swiss battle’

      • Frank Bridel

      Pages 29-34

   5. Experimentation and the law

      • Jean-Marc Varaut

      Pages 35-38

   6. Experimentation on animals: Animals as machines and animals as fetishes

      • Janine Chanteur

      Pages 39-46

4. Recent Progress of Medicine Requiring the Use of Animals

   1. Front Matter

      Pages 47-47

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   2. The role of animal experiments in pharmacological brain research

      • Arvid Carlsson

      Pages 49-56

   3. Regeneration of the nervous system

      • Alfredo Gorio, Flaminio Cattabeni

      Pages 57-69

   4. Endocrine glands, neuroendocrinology and animal experimentation

      • Paolo Preziosi

      Pages 71-80

   5. Laboratory animals and cardiovascular pathology: Means for better use

      • Jean Sassard

      Pages 81-87

   6. The importance of animal models for hypertension research

      • D. Ganten, K. Lindpaintner, Th. Unger, J. Mullins

      Pages 89-96

   7. Animal experiments and recent progress in thrombosis research

      • Giovanni de Gaetano, Chiara Cerletti, Andreina Poggi, Maria Benedetta Donati

      Pages 97-109

   8. Models of human renal disease

      • Carla Zoja, Norberto Perico, Giuseppe Remuzzi

      Pages 111-123

   9. The necessity of animal experimentation in tumor immunology

      • Guido Forni, Patrizia Caretto, Paola Ferraiorni, Maria Carla Bosco, Mirella Giovarelli

      Pages 125-132

   10. The use of animals in cancer chemotherapy

       • T. A. Connors

       Pages 133-140

   11. The use of experimental animals in transplantation research

       • D. W. van Bekkum

       Pages 141-151

   12. Animal models for AIDS research

       • Peter Bentvelzen

       Pages 153-161

Scientists are coming under increasing pressure from activist groups to stop animal experimentation, branded as cruel and unnecessary for improving human health. This attitude, however, stems from an unrealistic evaluation of the situation and distorted information about present scientific knowledge. There is no question that most medical progress - perhaps all, in fac- has been attained through knowledge derived initially from experiments in various animal species. There is practically no way of replacing animals in these investigations and so-called 'alternative methods' are in reality merely complementary. Tissue cultures, cell, microorganisms, enzymes, membranes, mathematical models - all are useful for preliminary screening tests and for testing hypotheses, but the complexity of a living organism is such that in vivo studies are essential before any test can responsibly be made in man. This book presents the proceedings of an international symposium organized in Strasbourg (October 24-25, 1988), with the aim of assessing present-day requirements as regards animal experimentation in research related to major medical and toxicological problems still awaiting solutions.

• AIDS
• Laboratory
• Tumor
• biology
• gene therapy
• transplantation

`This book should be read by all medical scientists and practising doctors, and also by any intelligent layman who wishes to be informed on an increasingly contentious issue. The book is properly and nicely printed ...'
Adverse Drug Reactions, 9/3, 1990

• Pharmacological Research Institute ‘Mario Negri’, Milan, Italy

  S. Garattini

• Radiobiological Institute ‘TNO’, Rijswijk, The Netherlands

  D. W. Bekkum

Policies and ethics