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Mitochondrial Medicine

Volume 1: Targeting Mitochondria

  • Book
  • © 2021

Overview

Editors:
  1. Volkmar Weissig

    1. Department of Pharmaceutical Sciences, Midwestern University, College of Pharmacy, Glendale, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Marvin Edeas

    1. Cochin Hospital, Cochin Institute, INSERM U1016, Paris, France

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Methods in Molecular Biology (MIMB, volume 2275)

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Table of contents (28 protocols)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Using QSAR Models to Predict Mitochondrial Targeting by Small-Molecule Xenobiotics Within Living Cells

    • Richard W. Horobin
    Pages 1-11

  3. DQAsomes as the Prototype of Mitochondria-Targeted Pharmaceutical Nanocarriers : An Update

    • Volkmar Weissig, Maria Lozoya, Nusem Yu, Gerard G. M. D’Souza
    Pages 13-25

  4. Synthesis and Characterization of Mitochondria-Targeted Triphenylphosphonium Bolaamphiphiles

    • Francesca Ceccacci, Simona Sennato, Edoardo Rossi, Raffaele Proroga, Stefano Sarti, Marco Diociaiuti et al.
    Pages 27-47

  5. Synthesis and Evaluation of 18F-Labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging

    • Dong-Yeon Kim, Jung-Joon Min
    Pages 49-64

  6. Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear β-Phosphorylated Nitrones : Preparation, 31P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Antiapoptotic Properties

    • Consuelo Petrocchi, Sophie Thétiot-Laurent, Marcel Culcasi, Sylvia Pietri
    Pages 65-85

  7. Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as Exomarkers of Mitochondrial Hydrogen Peroxide

    • Andrew G. Cairns, Stephen J. McQuaker, Michael P. Murphy, Richard C. Hartley
    Pages 87-117

  8. Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes

    • Parul Benien, Mohammed Almuteri, Shrey Shah, Mark Böhlke, Ahmed Mehanna, Gerard G. M. D’Souza
    Pages 119-126

  9. Imaging Mitochondrial Hydrogen Peroxide in Living Cells

    • Alexander R. Lippert, Bryan C. Dickinson, Elizabeth J. New
    Pages 127-140

  10. Synthesis and Testing of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin

    • Lucia Biasutto, Andrea Mattarei, Cristina Paradisi
    Pages 141-160

  11. Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria

    • Fernando Cagide, Catarina Oliveira, José Teixeira, Paulo J. Oliveira, Fernanda Borges
    Pages 161-172

  12. Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis

    • Samayita Ganguly, Tamer Elbayoumi
    Pages 173-186

  13. Mt-fura-2, a Ratiometric Mitochondria-Targeted Ca2+ Sensor. Determination of Spectroscopic Properties and Ca2+ Imaging Assays

    • Andrea De Nadai, Nicola Vajente, Diana Pendin, Andrea Mattarei
    Pages 187-215

  14. Sequence-Specific Control of Mitochondrial Gene Transcription Using Programmable Synthetic Gene Switches Called MITO-PIPs

    • Takuya Hidaka, Hiroshi Sugiyama, Ganesh N. Pandian
    Pages 217-225

  15. Targeting the Mitochondrial Genome Via a MITO-Porter : Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function

    • Yuma Yamada, Hideyoshi Harashima
    Pages 227-245

  16. mTRIP, an Imaging Tool to Investigate Mitochondrial DNA Dynamics in Physiology and Disease at the Single-Cell Resolution

    • Laurent Chatre, Miria Ricchetti
    Pages 247-263

  17. Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots

    • Ye Zhang, Hong Bi
    Pages 265-277

  18. Norbormide-Based Probes and Their Application for Mitochondrial Imaging in Drosophila Melanogaster

    • Alessia Forgiarini, Zifei Wang, Sergio Bova, Margaret Anne Brimble, Brian Hopkins, David Rennison et al.
    Pages 279-289

  19. Live-Cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine

    • Sander Grefte, Werner J. H. Koopman
    Pages 291-299

  20. Protein Supercomplex Recording in Living Cells Via Position-Specific Fluorescence Lifetime Sensors

    • Bettina Rieger, Karin B. Busch
    Pages 301-314
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Keywords

About this book

This second edition offers 88 chapters divided among three volumes providing the most comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine. Volume I guides readers through chapters on QSAR models, DQAsomes, synthesis of Triphenylphosphonium Phospholipid Conjugates, testing of novel isomeric mitochondriotropic derivatives, mTRIP, mitochondria-targeted imaging nanoplatforms, live-cell assessment, mitochondrial coenzyme Q10, rat liver Mitochondrial Lipidome, and Mito-SinCe2. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, application details for both the expert and non-expert reader, and tips on troubleshooting and avoiding known pitfalls.

 

Authoritative and accessible, Mitochondrial Medicine, Second Edition, Volume 1: Targeting Mitochondria aims to be a comprehensive source of know-how in the wide-ranging field of Mitochondrial Medicine.

Editors and Affiliations

  • Department of Pharmaceutical Sciences, Midwestern University, College of Pharmacy, Glendale, USA

    Volkmar Weissig

  • Cochin Hospital, Cochin Institute, INSERM U1016, Paris, France

    Marvin Edeas

Bibliographic Information

  • Book Title: Mitochondrial Medicine

  • Book Subtitle: Volume 1: Targeting Mitochondria

  • Editors: Volkmar Weissig, Marvin Edeas

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-0716-1262-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media, LLC, part of Springer Nature 2021

  • Hardcover ISBN: 978-1-0716-1261-3Published: 13 June 2021

  • Softcover ISBN: 978-1-0716-1264-4Published: 13 June 2021

  • eBook ISBN: 978-1-0716-1262-0Published: 12 June 2021

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XV, 459

  • Number of Illustrations: 56 b/w illustrations, 72 illustrations in colour

  • Topics: Molecular Medicine

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