Overview
- Authors:
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Michael Swash
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St. Bartholomew’s and The Royal London Hospital School of Medicine and Dentistry at Queen Mary Westfield College, and The Royal London Hospital, London, UK
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Martin S. Schwartz
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Atkinson Morley’s Hospital, London, UK
St George’s Hospital, London, UK
theoretical information that will be useful to managing patients with neuromuscular problems.
Both authors are recognised experts in the field of neuromuscular disorders and the book is based on their extensive and continuing clinical and research experience.
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Table of contents (21 chapters)
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Front Matter
Pages i-xviii
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- Michael Swash, Martin S. Schwartz
Pages 1-17
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- Michael Swash, Martin S. Schwartz
Pages 19-42
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- Michael Swash, Martin S. Schwartz
Pages 43-68
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- Michael Swash, Martin S. Schwartz
Pages 69-84
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- Michael Swash, Martin S. Schwartz
Pages 85-87
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- Michael Swash, Martin S. Schwartz
Pages 89-120
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- Michael Swash, Martin S. Schwartz
Pages 121-132
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- Michael Swash, Martin S. Schwartz
Pages 133-160
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- Michael Swash, Martin S. Schwartz
Pages 161-172
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- Michael Swash, Martin S. Schwartz
Pages 173-200
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- Michael Swash, Martin S. Schwartz
Pages 201-255
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- Michael Swash, Martin S. Schwartz
Pages 257-283
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- Michael Swash, Martin S. Schwartz
Pages 285-306
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- Michael Swash, Martin S. Schwartz
Pages 307-341
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- Michael Swash, Martin S. Schwartz
Pages 343-362
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- Michael Swash, Martin S. Schwartz
Pages 363-375
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- Michael Swash, Martin S. Schwartz
Pages 377-413
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- Michael Swash, Martin S. Schwartz
Pages 415-424
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- Michael Swash, Martin S. Schwartz
Pages 425-432
About this book
Nine years have elapsed since the second edition of this book was published. In this time the principal advances in neuromuscular diseases have been in the application of molecular genetics to understanding the aetiology and pathogenesis of this group of disorders. As a result many previously unrecognised disorders have been charac terised. Some clinical syndromes, such as the limb girdle dystrophies, have become better defined. In many such instances the new genetic information has led to major advances in knowledge of the biology of cell structures, for example, the membrane structural and channel proteins. The clinical syndromes themselves, and their patho logical and electrophysiological characteristics, however, remain as important as ever, since they constitute the clinical problem itself and, indeed, the database from which all other concepts emerge. Knowledge of the pathogenesis, genetics, and molecular biology of neuromuscular disorders is essential both in developing and applying new therapies and preventive measures, and in formulating genetic and prognostic advice. However, this informa tion does not necessarily always define clinically useful syndromes. Myotonia, for example, is an electrophysiological finding in some syndromes in which it is un detectable by clinical examination, although the phenomenon itself was originally defined as a clinical entity. The limb girdle muscular dystrophy syndromes can be defined by severity, distribution of weakness, age of onset, sex distribution and other characteristics and many of these can be better understood by study of the under lying defect in cell structural proteins.
Authors and Affiliations
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St. Bartholomew’s and The Royal London Hospital School of Medicine and Dentistry at Queen Mary Westfield College, and The Royal London Hospital, London, UK
Michael Swash
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Atkinson Morley’s Hospital, London, UK
Martin S. Schwartz
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St George’s Hospital, London, UK
Martin S. Schwartz
