Tobacco Smoking and Nicotine

1. Front Matter

   Pages i-ix

   PDF

2. Tobacco and Health Overview

   1. Tobacco and Health Overview

      • William R. Martin

      Pages 1-13

3. Tobacco Use and Associated Health Risks

   1. Tobacco Use and Associated Health Risks

      • D. Layten Davis

      Pages 15-23

4. Behavioral Effects of Nicotine and Dependence in Humans and Animals

   1. Nicotine Intake and Its Regulation by Smokers

      • M. A. H. Russell

      Pages 25-50

   2. The Functions of Smoking

      • David M. Warburton

      Pages 51-61

   3. Nicotine Increases Mental Efficiency: But How?

      • Keith Wesnes

      Pages 63-79

   4. Nicotine: Abuse Liability, Dependence Potential and Pharmacologic Treatment of Dependence

      • Jack E. Henningfield, Steven R. Goldberg, Donald R. Jasinski

      Pages 81-99

   5. Nicotine Actions in Models of Learning/Memory and Reward

      • Edgar T. Iwamoto, Paul J. Fudala, William R. Mundy, Edwin C. Williamson

      Pages 101-111

   6. Discriminative Stimulus Effects of Nicotine: Correlation with Binding Studies

      • I. P. Stolerman, R. Kumar, J. A. Pratt, C. Reavill

      Pages 113-124

   7. Noncholinergic Mechanisms Involved in the Behavioral and Stimulus Effects of Nicotine, And Relationships to the Process of Nicotine Dependence

      • John A. Rosecrans

      Pages 125-139

   8. Intracranial Self-Stimulation Studies with Nicotine

      • Paul B. S. Clarke, R. Kumar

      Pages 141-149

   9. Autoradiographical Evidence of Nicotinic Receptors in Rat Brain

      • P. B. S. Clarke, A. Pert

      Pages 151-167

   10. Nicotinic Modulation of Dopaminergic Neurotransmission: Functional Implications

       • Agu Pert, Paul B. S. Clarke

       Pages 169-189

5. Neurohumoral Regulation of Neuroendocrine and Cardiovascular Function by Nicotine

   1. Current Concepts on the Effects of Nicotine on Neurotransmitter Release in the Central Nervous System

      • Peter P. Rowell

      Pages 191-208

   2. Mechanisms of Nicotine Regulation of Dopamine Release in Neostriatum

      • Thomas C. Westfall, Holly Perry, Lillian Vickery

      Pages 209-223

   3. Effects of Nicotine and Exposure to Cigarette Smoke on Discrete Dopamine and Noradrenaline Nerve Terminal Systems of the Telencephalon and Diencephalon of the Rat: Relationship to Reward Mechanisms and Neuroendocrine Functions and Distribution of Nicotinic Binding Sites in Brain

      • K. Fuxe, K. Andersson, P. Eneroth, A. Härfstrand, A. Nordberg, L. F. Agnati

      Pages 225-262

   4. Nicotinic Regulation of Sympathoadrenal Catecholamine Secretion: Cross-Tolerance to Stress

      • Glen R. Van Loon, Judith A. Kiritsy-Roy, Laura V. Brown, Frances A. Bobbitt

      Pages 263-276

   5. Central Nicotinic Regulation of Arterial Blood Pressure

      • T. Kubo

      Pages 277-286

   6. Control of Blood Pressure by Muscarinic and Nicotinic Receptors in the Ventrolateral Medulla

      • Hreday N. Sapru

      Pages 287-300

   7. Stereoselectivity of Nicotine’s Central Effects and Its Relationship to Pain and Cardiovascular Function

      • Billy R. Martin

      Pages 301-316

Nicotine is the major factor in the continuation of the smoking habit among humans. On December 2-4, 1985, under the sponsorship of the Tobacco and Health Research Institute in Lexington, Kentucky, leading scientists from around the world whose research efforts have focused on the role of nicotine in the tobacco habit participated in an International Symposium to provide the most comprehensive and ~xtensive coverage of this topic so far. The material discussed was in the forefront of man's knowledge about nicotine, and both lectures and question and answer sessions were stimulating and enlightening. This publication contains the manuscripts presented at the Symposium, along with an Overview prepared by selected individuals. Lecture and poster session topics are delineated more fully in the Overview. This volume is expected to serve as a definitive reference on nicotine as it relates to the tobacco habit. Symposium sessions were arranged under four headings: (1) behavioral effects of nicotine and nicotine~ependence in humans and animals, (2) neurohumoral regulation of neuroendocrine and cardiovascular function by nicotine, (3) neuropharmacology of nicotine, and (4) neurochemistry. This was the first assembly of this magnitude of scientists who had devoted years of research to nicotine and its effects. Indeed, it was a pleasure to have sponsored this important event. Dr. Lay ten Davis, Director Tobacco and Health Research Institute Cooper and Alumni Drives Lexington, KY 40546-0236 v ACKNOWLEDGMENTS The Editors of this volume express sincere appreciation to all of the contributors. Special acknowledgments are given to Ms.

• CNS
• animals
• behavior
• brain
• dopamine
• metabolism
• methylation
• neuropharmacology
• opioid
• pharmacodynamics
• pharmacokinetics
• pharmacology
• primates
• receptor
• research

• Department of Pharmacology, University of Kentucky, Lexington, USA

  William R. Martin

• Department of Medicine, Veterans Administration Medical Center University of Kentucky, Lexington, USA

  Glen R. Loon

• Department of Pharmacology College of Medicine, University of Kentucky, Lexington, USA

  Edgar T. Iwamoto

• The Tobacco and Health Research Institute, University of Kentucky, Lexington, USA

  Edgar T. Iwamoto

• Tobacco and Health Research Institute, University of Kentucky, Lexington, USA

  Layten Davis

Policies and ethics