Atherosclerosis

1. Front Matter

   Pages i-x

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2. Rudolph Altschul: Man and Scientist

   1. Rudolph Altschul: Man and Scientist

      • S. Fedoroff

      Pages 1-4

3. The Dynamic Vessel Wall

   1. Front Matter

      Pages 5-5

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   2. Natural History of Atherosclerosis

      • Stephen M. Schwartz, David Gordon, Josiah N. Wilcox

      Pages 7-31

   3. Adaptations of Mature and Developing Arteries to Local Hemodynamics

      • B. Lowell Langille

      Pages 33-52

   4. The Cytoskeleton of Arterial Smooth Muscle Cells During Development, Atheromatosis and Tissue Culture

      • Giulio Gabbiani, Laura Rubbia

      Pages 53-56

4. Vascular Wall Injury and Repair

   1. Front Matter

      Pages 57-57

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   2. Repair of Arterial Endothelium

      • Michael A. Reidy, Volkhard Lindner

      Pages 59-66

   3. The Role of the Cytoskeleton in Endothelial Repair

      • Avrum I. Gotlieb

      Pages 67-88

   4. Thrombin-Stimulated Endothelial Cell Functions: Monocyte Adhesion and PDGF Production

      • Paul E. DiCorleto, Carol de la Motte, Ravi Shankar

      Pages 89-97

5. Extracellular Matrix Interactions in Atherogenesis

   1. Front Matter

      Pages 99-99

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   2. Dynamic Responses of Collagen and Elastin to Vessel Wall Perturbation

      • F. W. Keeley

      Pages 101-114

   3. Dynamic Interaction of Proteoglycans

      • Thomas N. Wight

      Pages 115-125

   4. Endothelial Cell — Extracellular Matrix Interactions: Modulation of Vascular Cell Phenotype by Matrix Components and Soluble Factors

      • Joseph A. Madri

      Pages 127-135

6. Autocrine and Paracrine Control of Vascular Tissue

   1. Front Matter

      Pages 137-137

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   2. Regulation of PDGF Expression in Vascular Cells

      • Tucker Collins, Regina Young, Arturo E. Mendoza, Jochen W. U. Fries, Amy J. Williams, Parvez Sultan et al.

      Pages 139-152

   3. Endothelial Regulation of Vasomotor Tone in Atherosclerosis

      • David G. Harrison

      Pages 153-160

   4. Production of Cytokines by Vascular Wall Cells: An Update and Implications for Atherogenesis

      • Peter Libby, Harald Loppnow, James C. Fleet, Helen Palmer, Hong Mei Li, Stephen J. C. Warner et al.

      Pages 161-169

7. Thrombosis and Fibrinolysis

   1. Front Matter

      Pages 171-171

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   2. Hypoxia and Endothelial Cell Function: Alterations in Barrier and Coagulant Properties

      • Satoshi Ogawa, Masayasu Matsumoto, Jerold Brett, Matthias Clauss, David M. Stern

      Pages 173-185

This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.

• Pathogene
• anatomy
• biology
• development
• evolution
• memory

• University of Toronto, Toronto, Canada

  Avrum I. Gotlieb, B. Lowell Langille

• University of Saskatchewan, Saskatoon, Saskatchewan, Canada

  Sergey Fedoroff

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