Experimental and Clinical Metastasis

1. Front Matter

   Pages 1-1

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2. Introduction to Metastatic Diseases

   1. Front Matter

      Pages 1-1

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   2. Introduction

      • Julia V. Burnier, Miguel N. Burnier Jr.

      Pages 3-10

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   3. Interactions of Normal Tissues and Systems with Metastatic Cells: Impact on Location, Survival and Growth

      • Jennifer M Kirstein, Ann F. Chambers

      Pages 11-27

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3. Gene Properties of Metastatic Cells

   1. Front Matter

      Pages 29-29

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4. Gene properties of Metastatic CellsFinalRE

   1. Introduction to Metastasis Suppressor Genes

      • Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins

      Pages 31-36

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   2. Metastasis Suppressor Genes

      • Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins

      Pages 37-47

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   3. Metastatic Dormancy and Metastasis Suppressor Genes

      • Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins

      Pages 49-52

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   4. Clinical Implications

      • Jean-Claude Marshall, Silvin Bakalian, Claudia Maria de Oliveira Martins

      Pages 53-53

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5. Molecular Mechanisms of Tumor Growth and Spread

   1. Front Matter

      Pages 55-55

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6. IMolecular Mechanisms of Tumor Growth and Spread

   1. Cell Cycle Control and Growth Factor Systems in Metastasis

      • Jonathan Cools-Lartigue, Jonathan Spicer

      Pages 57-78

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   2. Regulation of Angiogenesis by Tumour Suppressor Pathways

      • Karen J. Lefebvre, Sarah Assadian, Wissal El-Assaad, Jose G. Teodoro

      Pages 79-99

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   3. Inflammatory Mediators in Tumorigenesis and Metastasis

      • Jeremy Dupaul-Chicoine, Maya Saleh

      Pages 101-127

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   4. Role of Stroma in Disease Progression

      • Nicholas R. Bertos, Morag Park

      Pages 129-147

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7. Methods of Tumor Dissemination

   1. Front Matter

      Pages 149-149

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   2. Local Invasion

      • Patricia Rusa Pereira

      Pages 151-164

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   3. Lymphatic Dissemination

      • Alexandre Nakao Odashiro

      Pages 165-176

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   4. Hematogenous Dissemination

      • Bruno F. Fernandes

      Pages 177-190

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   5. Other Methods of Tumor Dissemination

      • Abelardo A. Rodríguez-Reyes

      Pages 191-198

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8. Animal Models of Metastasis

   1. Front Matter

      Pages 199-199

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Metastatic disease is the most lethal aspect of human malignancies, making the understanding and continued research of the process of metastasis a crucial step in treating cancer. The proposed book, entitled “Experimental and Clinical Metastasis: A Comprehensive Review” aims to provide a clear and extensive review of the clinical and experimental implications of metastatic disease. This work focuses on recent contributions to the field of metastasis, and will highlight crucial findings in the molecular understanding of disseminated disease as well as standard and personalized medicine currently being investigated in the clinic. Topics will include, among many, gene properties of metastatic cells, molecular mechanisms of tumour growth and spread, animal models of metastasis, and clinical implications, markers and treatment for metastatic disease. With the participation of worldwide experts in the field of oncology, from major academic and government centres, this book will provide a leading manual for the study of the metastatic process, from benchside science to bedside care. In this light, the proposed book will facilitate classroom learning for both medical and graduate students, as well as serve as a tool for physicians and researchers interested in the metastatic process. In addition, this book will include the latest advances in basic science as well as leading technologies and theories of targeting metastatic cells. Most importantly, not only will basic and clinical aspects be discussed, but furthermore, the translational aspect of research in metastatic diseases will be emphasized.

• Cancer
• Disease
• Metastasis
• Metastatic
• Research

• Centre for Genomic Regulation, Barcelona, Spain

  Julia V. Burnier

• , Ophthalmology, Pathology, Medicine & Onc, McGill University Health Centre, Montreal, Canada

  Miguel N. Burnier, Jr.

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