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Microdialysis in Drug Development

  • Book
  • © 2013

Overview

Editors:
  1. Markus Müller

    1. Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria

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  • Authored by international experts
  • Provides a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development
  • Describes cutting edge field
  • Includes supplementary material: sn.pub/extras

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series (AAPS, volume 4)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
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  2. General Aspects

    1. Front Matter

      Pages 1-1
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    2. Introduction to the Microdialysis Technology

      • Markus Müller
      Pages 3-12

    3. Recovery and Calibration Techniques: Toward Quantitative Microdialysis

      • Elizabeth C. M. de Lange
      Pages 13-33

    4. Analytical Considerations for Microdialysis Sampling

      • Justin C. Cooley, Michael W. Ducey, Anne R. Regel, Pradyot Nandi, Susan M. Lunte, Craig E. Lunte
      Pages 35-66

    5. Regulatory Aspects of Microdialysis: A United States Food and Drug Administration Perspective

      • Chinmay Shukla, Jing Li, Robert Lionberger, Edward D. Bashaw
      Pages 67-80

  3. Specific Topics

    1. Front Matter

      Pages 81-81
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  4. Specific topics

    1. Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations

      • Margareta Hammarlund-Udenaes
      Pages 83-102

    2. Microdialysis in Antibiotic Research

      • Markus Zeitlinger, Sandrine Marchand, William Couet, Aline Barth, Hartmut Derendorf
      Pages 103-126

    3. Skin and Transdermal Drug Delivery

      • Eva Benfeldt
      Pages 127-142

    4. Translational Approaches for Predicting CNS Drug Effects Using Microdialysis

      • Elizabeth de Lange
      Pages 143-162

    5. Extracellular Amyloid-β Protein Dynamics in Alzheimer’s Disease

      • John R. Cirrito
      Pages 163-178

    6. Microdialysis in Pain Research

      • Martin Brunner
      Pages 179-196

    7. Microdialysis in Ocular Drug Development

      • Mitesh R. Patel, Nanda K. Mandava, Ashim K. Mitra
      Pages 197-222

    8. Microdialysis in Metabolic Research

      • Per-Anders Jansson
      Pages 223-241

    9. High Molecular Weight Targets and Treatments Using Microdialysis

      • Geraldine F. Clough, Julie A. Stenken, Martin K. Church
      Pages 243-268

    10. Complementary Techniques: Positron Emission Tomography

      • Oliver Langer
      Pages 269-282

    11. Open Flow Microperfusion: An Alternative Method to Microdialysis?

      • Thomas Pieber, Thomas Birngruber, Manfred Bodenlenz, Christian Höfferer, Selma Mautner, Katrin Tiffner et al.
      Pages 283-302

    12. Microdialysis in Internal Organs and Tumors

      • Robert Sauermann, Markus Zeitlinger
      Pages 303-333

  5. Back Matter

    Pages 335-338
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Keywords

About this book

A vast number of diagnostic and therapeutic decisions are based on measuring blood concentrations of molecules, yet most biochemical and pharmacological events actually take place in the tissues. Microdialysis is a key semi-invasive sampling technique to measure in vivo drug penetration to the target site in humans, the method being feasible in virtually every organ. Authored by international experts in this cutting edge field, this book will provide a comprehensive overview of microdialysis and its application for measuring drug distribution in drug development.

Editors and Affiliations

  • Allgemeines Krankenhaus, Department of Clinical Pharmacology, Medical University Vienna, Vienna, Austria

    Markus Müller

About the editor

Prof. Markus Müller, MD is Head of the Department of Clinical Pharmacology at the Medical University of Vienna in Austria. He is specialized in Internal Medicine and Clinical Pharmacology and is an international expert in clinical research. He has published over 80 articles on the use and methodology of microdialysis in clinical drug development.

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