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Viral Entry into Host Cells

  • Book
  • © 2013

Overview

Editors:
  1. Stefan Pöhlmann

    1. Institute for Virology, Hannover Medical School, Hannover, Germany
      German Primate Center, Göttingen, Germany

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  2. Graham Simmons

    1. Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, San Francisco, USA

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  • Provides a comprehensive overview of interplay between viral and cellular factors during virus entry
  • Reviews key processes underlying host cell entry of viruses
  • Discusses cellular entry of reoviruses

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 790)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Attachment Factors

    • Clare L. Jolly, Quentin J. Sattentau
    Pages 1-23

  3. Picornavirus Entry

    • Jeffrey M. Bergelson, Carolyn B. Coyne
    Pages 24-41

  4. Reovirus Receptors, Cell Entry, and Proapoptotic Signaling

    • Pranav Danthi, Geoffrey H. Holm, Thilo Stehle, Terence S. Dermody
    Pages 42-71

  5. Entry of Influenza Virus

    • Xiangjie Sun, Gary R. Whittaker
    Pages 72-82

  6. Filovirus Entry

    • Graham Simmons
    Pages 83-94

  7. Paramyxovirus Entry

    • Katharine N. Bossart, Deborah L. Fusco, Christopher C. Broder
    Pages 95-127

  8. Cellular Entry of Retroviruses

    • Dirk Lindemann, Imke Steffen, Stefan Pöhlmann
    Pages 128-149

  9. Class II Fusion Proteins

    • Yorgo Modis
    Pages 150-166

  10. Entry of Rhabdoviruses Into Animal Cells

    • Andrew D. Regan, Gary R. Whittaker
    Pages 167-177

  11. Entry of Herpesviruses into Cells: The Enigma Variations

    • Claude Krummenacher, Andrea Carfí, Roselyn J. Eisenberg, Gary H. Cohen
    Pages 178-195

  12. Back Matter

    Pages 197-199
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Keywords

About this book

For a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism. The multi-faceted interplay between viral and cellular factors during virus entry is a fascinating field of study, which can provide important insight into viral pathogenesis and define new targets for intervention. This book provides a comprehensive overview of this exciting field of research.

Editors and Affiliations

  • Institute for Virology, Hannover Medical School, Hannover, Germany

    Stefan Pöhlmann

  • German Primate Center, Göttingen, Germany

    Stefan Pöhlmann

  • Blood Systems Research Institute, and Department of Laboratory Medicine, University of California San Francisco, San Francisco, USA

    Graham Simmons

About the editors

STEFA N PÖHLMANN is Professor for Infection Biology and Head of the Infection Biology Unit of the German Primate Center. His research is focused on virus host cell interactions, particularly on the molecular processes underlying host cell entry of human immunodeficiency virus and emerging viruses. Stefan Pöhlmann received his academic degrees (Dr. rer. nat., venia legendi) from the Friedrich‑Alexander‑University Erlangen‑Nurnberg. Before his appointment at the German Primate Center, he worked as a postdoctoral fellow at the University of Pennsylvania, as a junior research group leader at the Friedrich‑Alexander‑University Erlangen‑Nurnberg and as an assistant professor at Hannover Medical School. He serves on the editorial board of the Journal of Virology and Virology and serves as academic editor for PLoS ONE.

GRAHAM SIMMONS is an Associate Investigator at Blood Systems Research Institute and Associate Professor in the Department of Laboratory Medicine at the University of California, San Francisco. He is interested in many aspects of viral entry, particularly for blood transfusion transmissible agents and other emerging and re‑emerging viruses that may be a threat to the blood supply. Graham Simmons received his doctoral training from the Institute of Cancer Research in London prior to performing an EMBO‑sponsored postdoctoral fellowship at the University of Pennsylvania.

Bibliographic Information

  • Book Title: Viral Entry into Host Cells

  • Editors: Stefan Pöhlmann, Graham Simmons

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-7651-1

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Hardcover ISBN: 978-1-4614-7650-4Published: 17 June 2013

  • eBook ISBN: 978-1-4614-7651-1Published: 24 July 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 199

  • Topics: Biomedicine general, Cell Biology

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