Nanotoxicology

This book takes a systematic approach to nanotoxicology and the developing risk factors associated with  nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures.

• Provides an introduction to nanostructures actually in use
• Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays
• Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity
• Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology

• Biogenically Synthecized Silver Nanoparticles
• Carbon Nanostructures and Cellular Systems Interaction
• Cytotoxicity
• Cytotoxicity Methodologies
• Cytotoxicity and Genotoxicity
• Econanotoxicology
• Ecotoxicity Nanoparticles Fish and Crustaceans
• Erythrocyte Toxicity Nanomaterials
• Genetic Studies Nanomaterial Effects
• Genotoxicity
• Genotoxicity Methodologies
• Interaction
• Iron Oxide Nanoparticles Cytotoxicity and Genotoxicity
• Nanoparticle Cytotoxicity
• Nanostability
• Nanostructure Internalization Cellular Mechanism
• Nanotoxicology
• Nanotoxicology Methodologies
• Poloxamer Drug-delivery Systems
• Polymeric Nanoparticles

• Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, Brazil

  Nelson Durán, Oswaldo L. Alves

• Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

  Silvia S. Guterres

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