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Mucosal Delivery of Biopharmaceuticals

Biology, Challenges and Strategies

  • Book
  • © 2014

Overview

Editors:
  1. José das Neves

    1. IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal

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  2. Bruno Sarmento

    1. NEWTherapies Group, INEB – Instituto de Engenharia Biomédica, Porto, Portugal

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  • Explores the biology of mucosal tissues and their interactions with biopharmaceuticals and their delivery systems

  • Highlights the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals

  • Examines technological strategies and challenges of creating new biopharmaceutical drugs

  • Includes supplementary material: sn.pub/extras

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xix
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  2. Biology of Mucosal Sites

    1. Front Matter

      Pages 1-1
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    2. Concepts in Mucosal Immunity and Mucosal Vaccines

      • Simona Gallorini, Derek T. O’Hagan, Barbara C. Baudner
      Pages 3-33

    3. Mucoadhesion and Characterization of Mucoadhesive Properties

      • Tao Yu, Gavin P. Andrews, David S. Jones
      Pages 35-58

    4. Mucus as a Barrier for Biopharmaceuticals and Drug Delivery Systems

      • Hongbo Zhang, Mohammed-Ali Shahbazi, Patrick V. Almeida, Hélder A. Santos
      Pages 59-97

    5. Epithelial Permeation and Absorption Mechanisms of Biopharmaceuticals

      • Hanne Mørck Nielsen
      Pages 99-122

  3. Delivery Strategies for Specific Mucosal Sites

    1. Front Matter

      Pages 123-123
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    2. Oral Delivery of Biopharmaceuticals

      • Catarina Oliveira Silva, Bruno Sarmento, Catarina Pinto Reis
      Pages 125-147

    3. Buccal Delivery of Biopharmaceuticals: Vaccines and Allergens

      • Sevda Şenel, Merve Cansız, Michael J. Rathbone
      Pages 149-168

    4. Pulmonary Delivery of Biopharmaceuticals

      • Fernanda Andrade, Catarina Moura, Bruno Sarmento
      Pages 169-195

    5. Nasal Delivery of Biopharmaceuticals

      • Eiji Yuba, Kenji Kono
      Pages 197-220

    6. Ocular Delivery of Biopharmaceuticals

      • Holly Lorentz, Heather Sheardown
      Pages 221-259

    7. Vaginal Delivery of Biopharmaceuticals

      • José das Neves
      Pages 261-280

  4. Case Studies of Mucosal Delivery of Biopharmaceuticals

    1. Front Matter

      Pages 281-281
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    2. Nanoparticles-in-Microsphere Oral Delivery Systems (NiMOS) for Nucleic Acid Therapy in the Gastrointestinal Tract

      • Shardool Jain, Mansoor Amiji
      Pages 283-312

    3. Bacteria-Based Vectors for Oral Gene Therapy

      • Yong Bai, Rachael Burchfield, Sangwei Lu, Fenyong Liu
      Pages 313-324

    4. Self-Assembled Polysaccharide Nanogels for Nasal Delivery of Biopharmaceuticals

      • Tomonori Nochi, Yoshikazu Yuki, Kazunari Akiyoshi, Hiroshi Kiyono
      Pages 325-332

    5. Pheroid™ Vesicles and Microsponges for Nasal Delivery of Biopharmaceuticals

      • Lissinda H. du Plessis, Awie F. Kotzé
      Pages 333-343

    6. Delivery Strategies for Developing siRNA-Based Vaginal Microbicides

      • Joseph A. Katakowski, Deborah Palliser
      Pages 345-365

    7. Delivery Strategies for Developing Vaginal DNA Vaccine Combining Cell-Penetrating Peptide and Jet Injection

      • Takanori Kanazawa, Hiroaki Okada
      Pages 367-378
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Keywords

About this book

Biopharmaceutical medicines, the newest class of therapeutics, are quite heterogeneous and include a range of molecules such as proteins, peptides, vaccines and nucleic acids, with use in virtually all therapeutic fields (e.g. cancer and infectious diseases, vaccination, metabolic dysfunctions) and diagnostics. This edited book gives a concise and up-to-date overview of the biological features justifying the use of different human mucosa as delivery routes for biopharmaceuticals, the technological strategies that have been followed so far regarding the optimization of mucosal potentialities as well as the challenges that arise with the advent of new biopharmaceutical drugs and alternative means of administration. Following a brief introduction, the first section addresses general aspects of the biology of mucosal tissues and their unique aspects toward beneficial or deleterious interaction with biopharmaceuticals and their delivery systems. The second part reviews the different delivery strategies that have recently been investigated for different mucosal sites. The third section describes the development and clinical applications of drug delivery systems and products enclosing biopharmaceuticals for mucosal delivery, with a focus on the most successful case studies of recent years. The last section briefly centers on relevant aspects of the regulatory, toxicological and market issues of mucosal delivery of biopharmaceuticals.​ Scientists and researchers in the fields of drug delivery, material science, biomedical science and bioengineering as well as professionals, regulators and policy makers in the pharmaceutical, biotechnology and healthcare industries will find in this book an important compendium of fundamental concepts and practical tools for their daily research and activities.

Editors and Affiliations

  • IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde, Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal

    José das Neves

  • NEWTherapies Group, INEB – Instituto de Engenharia Biomédica, Porto, Portugal

    Bruno Sarmento

About the editors

José das Neves is a researcher at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, and in the Faculty of Pharmacy, University of Porto, Portugal, where he earned a Ph.D. in Pharmaceutical Sciences. His previous work has spanned multiple aspects of the development of vaginal drug delivery systems, and his current research interests include the development of nanotechnology-based solutions for the development of anti-HIV microbicides and mucosal delivery of biopharmaceuticals.

Bruno Sarmento is an affiliated researcher at INEB – Instituto de Engenharia Biomédica, University of Porto, Portugal. He is also an assistant professor of pharmaceutical and biopharmaceutical technology at Instituto Superior de Ciências da Saúde-Norte, CESPU, Gandra, Portugal. He earned a Ph.D. in Pharmaceutical Technology at the University of Porto. He has extensive work in the development of nanocarriers for the oral delivery of biopharmaceuticals—namely insulin—and the establishment of novel in vitro intestinal permeability models. His current research focuses on nanomedicines and their applications in the pharmaceutical and biomedical fields.

Bibliographic Information

  • Book Title: Mucosal Delivery of Biopharmaceuticals

  • Book Subtitle: Biology, Challenges and Strategies

  • Editors: José das Neves, Bruno Sarmento

  • DOI: https://doi.org/10.1007/978-1-4614-9524-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4614-9523-9Published: 04 February 2014

  • Softcover ISBN: 978-1-4899-7838-7Published: 27 August 2016

  • eBook ISBN: 978-1-4614-9524-6Published: 03 February 2014

  • Edition Number: 1

  • Number of Pages: XIX, 601

  • Number of Illustrations: 111 b/w illustrations, 23 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Pharmacology/Toxicology

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