Antimutagenesis and Anticarcinogenesis Mechanisms III

1. Front Matter

   Pages i-xi

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2. Mechanistic Approaches to Antimutagenesis and Anticarcinogenesis

   1. Mechanisms of Antimutagenesis and Anticarcinogenesis: Role in Primary Prevention

      • Silvio De Flora, Alberto Izzotti, Carlo Bennicelli

      Pages 1-16

   2. Multiple Mechanisms: The Example of Vitamin A

      • Luigi M. De Luca

      Pages 17-25

3. Inhibition of Mutagenesis and Carcinogenesis by Extracellular Mechanisms

   1. Inhibition of Nitrosation

      • H. Bartsch, B. Pignatelli, S. Calmels, H. Ohshima

      Pages 27-44

   2. Protective Mechanisms of Dietary Fibers in Nutritional Carcinogenesis

      • John H. Weisburger, Bandaru S. Reddy, David P. Rose, Leonard A. Cohen, Marcia E. Kendall, Ernst L. Wynder

      Pages 45-63

   3. Extracellular Interception of Mutagens

      • D. M. Shankel, S. Kuo, C. Haines, L. A. Mitscher

      Pages 65-74

   4. Proteins as Scavengers of Nitrite: Antimutagenic Implications

      • Kiyomi Kikugawa, Tetsuta Kato

      Pages 75-85

   5. Antimutagenic Agents from Natural Products of Terrestrial and Marine Origin

      • Monroe E. Wall, Mansukh C. Wani

      Pages 87-97

   6. Inhibitory Effects of Dietary Leafy Vegetables on Mutagens and on Active Oxygens

      • Junko Ebata, Kazuaki Kawai, Hideyuki Furukawa

      Pages 99-102

   7. Extrapolation of in Vitro Antimutagenicity to the in Vivo Situation: The Case for Anthraflavic Acid

      • C. Ioannides, A. D. Ayrton, D. F. V. Lewis, R. Walker

      Pages 103-110

   8. Preventive Effect of Magnesium Hydroxide on Carcinogen-Induced Large Bowel Carcinogenesis in Rats

      • Hideki Mori, Yukio Morishita, Tukuro Shinoda, Takuji Tanaka

      Pages 111-118

   9. Antimutagenic Investigations on Commercial Yogurt

      • C. Della Croce, E. Morichetti, G. Bronzetti, C. Salvadori, E. Macri

      Pages 119-125

4. Modulation of Metabolism and Blocking of Reactive Species

   1. Chemoprotection by Inducers of Electrophile Detoxication Enzymes

      • Thomas W. Kensler, Nancy E. Davidson, John D. Groopman, Bill D. Roebuck, Hans J. Prochaska, Paul Talalay

      Pages 127-136

   2. Protective Role of Glutathione, Thiols, and Analogues in Mutagenesis and Carcinogenesis

      • Bengt Jernström, Ralf Morgenstern, Peter Moldéus

      Pages 137-147

   3. N-Acetylcysteine Inhibits Diesel Extract Mutagenicity in the Ames Test and SCE Induction in Human Lymphocytes

      • R. Barale, R. Micheletti, C. Sbrana, I. Glussich, C. Scapoli, I. Barrai

      Pages 149-160

   4. Sulfotransferase- and Acetyltransferase-Mediated Activation of Carcinogenic N-Hydroxyarylamines in Mammals and Bacteria, and Their Modulation by Thiols

      • Yasushi Yamazoe, Medhat Abu-Zeid, Norma Staiano, Ryuichi Kato

      Pages 161-169

   5. Induction of Rat Liver GSH Transferases by 1,2-Dithiole-3-Thione Illustrates Both Anticarcinogenic and Tumor-Promoting Properties

      • David J. Meyer, Brian Coles, Jonathan Harris, Kim S. Gilmore, Kevin Raney, Thomas M. Harris et al.

      Pages 171-179

   6. Organ-Specific Modification of Carcinogenesis by Antioxidants in Rats

      • Masao Hirose, Tomoyuki Shirai, Satoru Takahashi, Kumiko Ogawa, Nobuyuki Ito

      Pages 181-188

   7. The Modulating Effects of Antioxidants in Rat Embryos and Sertoli Cells in Culture

      • Diana Anderson, Anne J. Francis

      Pages 189-200

   8. Blocking the Plant Activation of Promutagenic Aromatic Amines by Peroxidase Inhibitors

      • Michael J. Plewa

      Pages 201-217

Lifestyle, in any part of the world, is associated with the occurrence of major chronic diseases, including coronary heart disease, hypertension, and stroke; many distinct types of cancer; and adult onset diabetes (11,22,70,75). One important element of lifestyle is tobacco use, which appreciably increases the risk of a number of chronic diseases (21). Other lifestyle factors relate to nutritional traditions, alcohol use, and exercise (11,30,58,60,70,71). The underlying evidence is, in part, based on the evidence of specific diseases in relation to dietary habits in a given geographic region, as well as changes in such disease occurrences in migrant populations from a low risk to a high risk area, and vice versa (25,42). Populations that customarily consume fruits and vegetables and also whole grain cereal products generally have a lower risk of cardiovascular diseases and specific types of cancer than populations with a lower intake of such foods, everything else being equal (63). In the last few years, research has provided mechanistic explanations as to the reasons for the protective effects of specific foods. This paper will emphasize the mechanisms whereby cancer risks are reduced by dietary modification.

• DNA
• RNA
• cancer
• carcinogenesis
• gene expression
• genes
• metabolism
• metastasis
• molecular control
• mutagen
• mutagenesis
• prevention
• research
• tumor
• tumor progression

• Istituto di Mutagenesi e Differenziamento del CNR, Pisa, Italy

  Giorgio Bronzetti

• Okayama University, Okayama, Japan

  Hikoya Hayatsu

• Istituto di Igiene e Medicina Preventia, Genova, Italy

  Silvio Flora

• U.S. Environmental Protection Agency, USA

  Michael D. Waters

• University of Kansas, Lawrence, USA

  Delbert M. Shankel

• USA

  Claire Wilson & Associates

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