Targeting of Drugs

1. Front Matter

   Pages iii-viii

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2. The Structure of Different Types of Liver Cells in Relation to Uptake and Exchange Processes

   • Albert Geerts, Luc Bouwens, Ronald De Zanger, Hans Van Bossuyt, Eddie Wisse

   Pages 1-14

3. The Lymphatic System in Drug Targeting: An Overview

   • J. G. Hall

   Pages 15-28

4. The Hepatic Receptor for Asialoglycoproteins: Search for a Function

   • J. Clifford Steer, Peretz Weiss, Peter J. Wirth, Gilbert Ashwell

   Pages 29-43

5. The Galactose-Particle Receptor on Liver Macrophages: Biological Function and Implications for Clearance of Particulate Material

   • Victoria Kolb-Bachofen

   Pages 45-51

6. Free Radicals in Health and Disease: Implications for Drug Delivery and Targeting

   • Catherine Rice-Evans

   Pages 53-67

7. Monoclonal Antibodies and Drug Targeting in Cancer

   • Karol Sikora

   Pages 69-79

8. Immunotoxins in Cancer Therapy

   • F. K. Jansen, C. Blazy, H. E. Blythman, B. Bourrie, P. Carayon, P. Casellas et al.

   Pages 81-91

9. Techniques for Ex-Vivo Bone Marrow Treatment with Immunotoxins

   • J. M. Derocq, G. Laurent, P. Casellas, H. Blythman, F. Jansen

   Pages 93-101

10. The Potential of Membrane-Acting Toxins for Targeted Cancer Therapy

    • Francis A. Drobniewski, Philip E. Thorpe, Philip M. Wallace, Edward J. Wawrzynczak

    Pages 103-108

11. In Vivo Uptake and Processing of Liposomes by Parenchymal and Non-Parenchymal Liver Cells; Application to Immunotherapeutic Treatment of Hepatic Metastases

    • Gerrit L. Scherphof, Toss Daemen, Hans Derksen, George Lázár, Halbe H. Spanjer, Frits H. Roerdink

    Pages 109-120

12. Platelet Activating Factor, a Potent Mediator of Allergy, as a Structural Component of Phosphatidylcholine Vesicles

    • E. Skrika, C. Vakirtzi-Lemonias

    Pages 121-135

13. Phospholipid Stereospecificity in Liposomal Modulation of Nitrogen Mustard Action

    • Carl Ritter, Charles Prood, Robert J. Rutman

    Pages 137-141

14. Niosomes: A Putative Drug Carrier System

    • A. J. Baillie

    Pages 143-151

15. The Immunoadjuvant Action of Liposomes: Optimization Studies

    • Gregory Gregoriadis, David Davis, Nathalie Garcon

    Pages 153-165

16. Targeting of Antigens to Antigen-Presenting Cells and their Activation: A Requirement for Vaccine Development

    • Anthony C. Allison, Noelene E. Byars

    Pages 167-176

17. Targeting Using Physical Approaches and Particulate Drug Carriers: Interaction with the Biological Milieu

    • S. S. Davis, Lisbeth Illum

    Pages 177-187

18. Pragmatic Approaches to Delivery of Peptides and Proteins as Drugs

    • Deborah A. Eppstein

    Pages 189-202

19. Reconstituted Influenza Virus Envelopes as a Potential Carrier for Fusion-Mediated Microinjection of Macromolecules into Living Cells

    • Abraham Loyter, Moshe Lapidot

    Pages 203-212

20. Back Matter

    Pages 213-222

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A major vehicle for the transition of carrier-mediated drug delivery from a theoretical/experimental status to one with practical uses has been the NATO Advanced Studies Institute series "Targeting of Drugs". Three previous ASls of the series[1-3], also held in Cape Sounion, dealt with carriers of natural and synthetic origin, their preparation and drug incorporation as well as a wide range of applications. This book contains the proceedings of the 4th NATO ASI "Targeting of Drugs: Anatomical and Physiological Considerations" held in Cape Sounion, Greece during 20 June - 1 July 1987. Historically, carrier systems have been chosen on the basis of selective affinity for target sites. For instance, monoclonal antibodies bind selectively to antigens on the surface of cells and the same applies to ligands such as certain glycoproteins which bind to cell receptors. Colloidal carriers on the other hand, are "passively" targeted to the reticuloendothelial system. However, effective drug delivery depends not only on demonstration of affinity of the carrier system for its target but also, and perhaps crucially, on the way(s) by which the carrier-drug entity interacts with the interposed biological milieu. The book deals in depth with a number of biological milieus as travelled space for carriers en route to their destination, difficulties arising from unfavorable milieu-carrier interactions and ways to circumvent such difficulties. It also identifies, when possible, situations where proposed uses would or would not be realistic and provides perspectives for future goals.

• Antigen
• bone
• cancer
• cancer therapy
• cell
• drug
• drug delivery
• lipide
• research
• vaccine

From Book News, Inc.
Proceedings of the conference held June 20-July 1, 1987 in Cape Sounion, Greece. Contributors deal in depth with numerous biological milieus as travelled space for carriers enroute to their destination, difficulties arising from unfavorable milieu-carrier interactions, and ways to circumvent such difficulties. Situations where proposed uses would or would not be realistic are also identified. Liberal use of graphics. Produced from uniform typescript.
Annotation copyright Book News, Inc. Portland, Or.

• Royal Free Hospital School of Medicine, London, UK

  Gregory Gregoriadis

• Smith Kline & French Laboratories, Philadelphia, USA

  George Poste

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