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Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

Volume 1

  • Book
  • © 1990

Overview

Editors:
  1. Toshiharu Nagatsu

    1. Nagoya University School of Medicine, Nagoya, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Abraham Fisher

    1. Israel Institute for Biological Research, Ness-Ziona, Israel

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    You can also search for this editor in PubMed   Google Scholar

  3. Mitsuo Yoshida

    1. Jichi Medical School, Tochigi, Japan

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Part of the book series: Advances in Behavioral Biology (ABBI, volume 38A)

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Table of contents (161 chapters)

  1. Front Matter

    Pages i-xxi
    Download chapter PDF

  3. Amyloid

    1. Molecular Genetics of Alzheimer’s Disease

      • John Hardy
      Pages 19-22

    2. Proteins and Proteolysis in the Pathogenesis of Alzheimer’s Disease

      • George G. Glenner
      Pages 23-27

    3. Amyloid β Protein Precursors having Proteinase Inhibitor Regions are Highly Expressed in Alzheimer’s Disease Brains

      • Nobuya Kitaguchi, Yasuyuki Takahashi, Yasuo Tokushima, Kiyomi Oishi, Satoshi Shiojiri, Seigo Tanaka et al.
      Pages 29-35

    4. Differential Expression of Three Types of Amyloid Protein Precursor mRNA in Alzheimer’s Disease Brain

      • Seigo Tanaka, Yasuyuki Takahashi, Satoshi Shiojiri, Nobuya Kitaguchi, Hirataka Ito, Kunihiro Ueda et al.
      Pages 37-40

    5. Protease Inhibitor and Cholinergic System in Alzheimer’s Disease

      • Shigenobu Nakamura, Seigo Tanaka, Wataru Araki, Teruyuki Tsuji, Shingo Kawashima, Satoshi Shiojiri et al.
      Pages 41-46

    6. Structure and Expression of mRNA for the Mouse Homolog of Alzheimer Amyloid Beta Protein Precursor

      • Takeshi Yamada, Ryutaro Izumi, Hiroyuki Sasaki, Hirokazu Furuya, Ikuo Goto, Yoshiyuki Sasaki
      Pages 47-50

    7. Molecular Cloning and Structural Analysis of the Human Amyloid ß Protein Precursor Gene

      • Shun-ichi Yoshikai, Hiroyuki Sasaki, Katumi Doh-ura, Hirokazu Furuya, Yoshiyuki Sakaki
      Pages 51-53

    8. Protease Nexin 1 Immunoreactivity in Senile Plaques in Alzheimer Disease and Aged Brain

      • Yoshio Namba, Kazuhiko Ikeda, Masanori Tomonaga
      Pages 55-58

    9. Monoclonal Antibodies Against Senile Plaque Amyloid in Alzheimer’s Disease

      • Yuji Aizawa, Ryo Fukatsu, Yuji Takamaru, Kayo Tsuzuki, Tosyiyuki Obara, Mitsuru Fujii et al.
      Pages 59-63

    10. Identification of Putative Amyloid A4-Splitting Enzymes with Two Endopeptidases Widely Distributed in Mammalian Cells

      • Shoichi Ishiura, Toshifumi Tsukahara, Takeshi Tabira, Koichi Suzuki, Hideo Sugita
      Pages 65-68

    11. Proteolytic Processing of β-Protein Precursor-Related Synthetic Peptides

      • Carmela R. Abraham, Huntington Potter
      Pages 69-74

    12. Degeneration of Neuronal Processes in Rats Induced by the Protease Inhibitor Leupeptin

      • Shigeru Takauchi, Koho Miyoshi
      Pages 75-78

    13. α 1-Antichymotrypsin Influences the Survival of Neurons

      • Hiroko Kanai, Makoto Tanaka, Shunsaku Hirai
      Pages 79-82

    14. Evidence for a Neuronal Origin of Senile Plaques in Down’s Syndrome Brains

      • David Allsop, Sei-ichi Haga, Chie Haga, Tsuyoshi Ishii
      Pages 83-86

    15. Serum Amyloid P Immunoreactivity in Cortical Tangles, Plaques and Vessels in Alzheimer’s Disease: Implications for Dysfunction of the Blood-Brain Barrier?

      • Rajesh N. Kalaria
      Pages 87-90

    16. Monoamine Oxidase B Activity in Senile Plaque

      • Shinichi Nakamura, Osamu Yasuhara, Toshio Kawamata, Toru Kimura, Ichiro Akiguchi, Jun Kimura et al.
      Pages 91-94
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Keywords

About this book

This two-volume work contains the full text of the oral and poster presentations and the general discussion at the round table discussion of the Second International Conference on Alzheimer's and Parkinson's Diseases: Basic and Therapeutic Strategies, held at the Kyoto Park Hotel in Kyoto, Japan, on November 6-10, 1989. The First Conference was held at the Aviya Sonesta Hotel in Eilat, Israel, on March 24-27, 1985. The record of this First Conference was published by Plenum Press in 1986 as Volume 29 in Advances in Behavioral Biology, under the title "Alzheimer's and Parkinson's Diseases: Strategies for Research and Development." We are happy that the comprehensive texts of the oral and poster presentations of the Second Conference could again be published within the framework of this series. Since the First Conference in 1985, rapid progress has been made in both basic and 'therapeutic aspects of these diseases. About 700 scientists from allover the world participated in the Second Conference, and 300 papers were presented in oral and poster sessions. Many people and organizations have helped to organize this multi­ disciplinary international conference and hence have contributed to the scientific quality of these two volumes. We thank the members of the organizing committee, the organizations that provided financial support, and the contributing scientists for their enthusiastic participation. These two volumes follow the same publishing philosophy as the volume derived from the First Conference. They span a broad spectrum of topics and bridge preclinical and clinical concepts related to these diseases.

Editors and Affiliations

  • Nagoya University School of Medicine, Nagoya, Japan

    Toshiharu Nagatsu

  • Israel Institute for Biological Research, Ness-Ziona, Israel

    Abraham Fisher

  • Jichi Medical School, Tochigi, Japan

    Mitsuo Yoshida

Bibliographic Information

  • Book Title: Basic, Clinical, and Therapeutic Aspects of Alzheimer’s and Parkinson’s Diseases

  • Book Subtitle: Volume 1

  • Editors: Toshiharu Nagatsu, Abraham Fisher, Mitsuo Yoshida

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5844-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1990

  • Softcover ISBN: 978-1-4684-5846-6Published: 08 July 2012

  • eBook ISBN: 978-1-4684-5844-2Published: 06 December 2012

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: 830

  • Number of Illustrations: 396 b/w illustrations, 8 illustrations in colour

  • Topics: Pathology, Pharmacology/Toxicology, Neurosciences

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