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Pharmacology of Hormonal Polypeptides and Proteins

Proceedings of an International Symposium on the Pharmacology of Hormonal Polypeptides, held in Milan, Italy, September 14–16, 1967

  • Conference proceedings
  • © 1968

Overview

Editors:
  1. Nathan Back

    1. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, USA

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  2. Luciano Martini

    1. Institute of Pharmacology, University of Milan, Milan, Italy

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  3. Rodolfo Paoletti

    1. Institute of Pharmacology, University of Cagliari, Cagliari, Italy

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 2)

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Table of contents (76 papers)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Peptide and Protein Chemistry

    1. Some New Methods in Peptide Synthesis

      • Iphigenia Photaki
      Pages 1-10

    2. Novel Techniques in Peptide Synthesis

      • A. Patchornik
      Pages 11-16

    3. Synthetic polypeptides with enhanced biological activities

      • R. A. Boissonnas
      Pages 17-17

    4. Synthesis of Gastrointestinal Hormones

      • Miguel A. Ondetti, John T. Sheehan, M. Bodanszky
      Pages 18-31

    5. The Synthesis of Caerulein

      • L. Bernardi, G. Bosisio, R. de Castiglione, O. Goffredo
      Pages 32-34

    6. Techniques for the Synthesis of Acth And Msh Peptides and Analogues

      • W. Rittel
      Pages 35-47

    7. Studies with Tryptophan in Solid-Phase Synthesis

      • Garland R. Marshall
      Pages 48-52

  3. Posterior Pituitary Hormones

    1. Oxytocin — Molecular Aspects

      • B. Berde
      Pages 53-65

    2. Oxytocin and Vasopressin: Biochemical Considerations

      • J. Rudinger, V. Pliška, I. Rychlík, F. Šorm
      Pages 66-72

    3. Neurophysin, Oxytocin and Vasopressin in Neurosecretory Granules and in Crystalline Complexes

      • D. B. Hope
      Pages 73-83

    4. Mechanism of Release and Mechanism of Action of Vasopressin

      • Niels A. Thorn
      Pages 84-92

    5. Radioimmunoassay of Oxytocin

      • Seymour M. Glick, Mary Wheeler, Avir Kagan, Perianna Kumaresan
      Pages 93-100

    6. Comparison of the Pharmacological Properties of Two Highly Potent, Crystalline Neurohypophyseal Hormone Analogs: Deamino-1-Seleno-Oxytocin and Deamino-Oxytocin

      • Roderich Walter, Irving L. Schwartz
      Pages 101-104

  4. Hypothalamic Neurohumoral Principles

    1. Structure and Function of Pituitary Grafts, Related to the Problem of Hypothalamic Control of Hypophyseal Activity

      • L. Desclin, J. Flament-Durand
      Pages 105-111

    2. The Physiology and Biochemistry of Luteinizing Hormone-Releasing Factor and Follicle Stimulating Hormone-Releasing Factor

      • S. M. McCann, S. Watanabe, D. B. Crighton, D. Beddow, A. P. S. Dhariwal
      Pages 112-122

    3. Studies on the Isolation of Luteinizing Hormone Releasing Factor (LRF)

      • H. Gregory, A. L. Walpole, H. M. Charlton, G. W. Harris, May Reed
      Pages 123-127

    4. Studies on Luteinizing Hormone Releasing Factor (LRF) in Hypophysial Portal Blood of Rats

      • G. Fink
      Pages 128-137

    5. Studies on the Mechanism of Action of Hypothalamic FSH- and LH-Releasing Factors

      • M. Jutisz, A. Berault, M. P. de la Llosa
      Pages 138-147

    6. Thyrotropin-Releasing Factor (TRF) of Hypothalamic Origin. A Review of Physiological and Biochemical Studies

      • Roger Guillemin
      Pages 148-157
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Keywords

About this book

It can be concluded (under the specific experimental procedures em­ ployed) that:- 1) HCG labelled with 1 - 2 atoms of radioactive iodine did not differ sig­ nificantly from the unlabelled hormone; 2) The ovary alone exhibited a capacity to affix specifically HCG; 3) The amount of radioactive material in the ovary was directly proport­ ional to the quantity of labelled HCG injected; 4) When the HCG present in the circulation is bound to an antiserum to HCG, the antigen-antibody complex is not concentrated by the ovary; 5) Circulating labelled HCG decreased to 50% within 30 minutes following a single intravenous injection; 6) There are four different phases of ovarian uptake of HCG, namely:­ the first phase, when there is only an inflow from the circulation and stor­ age mainly in the follicular envelopes; the second phase, when there is a greater inflow than outflow; the third phase, when the inflow is equal to the outflow; and the fourth period, when the outflow is bigger than the in­ flow. REFERENCES 1. Lunenfeld, B. and Eshkol, A. Vitamins and Hormones (1967) 25:165 2. Eshkol, A. In: Recent Research on Gonadotropbio Hormones, eds. E. T. Bell andJ. A. Loraine, Edinburgh, Livingstone (1967), p. 202. 3. Eshkol, A. and Lunenfeld, B. Proc. Tel-Hashomer Hosp. (1967) 6:4. ACKNOWLEOOMEN'IS This work was supported in part by a grant from the Population Council, N. Y. , U. S. A. andbyGrantNo.

Editors and Affiliations

  • Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, USA

    Nathan Back

  • Institute of Pharmacology, University of Milan, Milan, Italy

    Luciano Martini

  • Institute of Pharmacology, University of Cagliari, Cagliari, Italy

    Rodolfo Paoletti

Bibliographic Information

  • Book Title: Pharmacology of Hormonal Polypeptides and Proteins

  • Book Subtitle: Proceedings of an International Symposium on the Pharmacology of Hormonal Polypeptides, held in Milan, Italy, September 14–16, 1967

  • Editors: Nathan Back, Luciano Martini, Rodolfo Paoletti

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-4612-5

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1968

  • Softcover ISBN: 978-1-4899-2726-2Published: 07 December 2013

  • eBook ISBN: 978-1-4614-4612-5Published: 11 December 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XI, 660

  • Topics: Pharmacology/Toxicology, Protein Science

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