- Features step-wise protocols for assays used in immunotoxicity safety evaluations
- Provides helpful hints to overcome assay problems or increased assay viability
- Includes chapters covering both clinical evaluation and alternative approaches
- Offers discussions of new assays likely to impact future testing protocols
- Presents discussions of age and gender considerations in immune safety testing
- Incorporates testing approaches designed to address emerging immune health risk concerns
Buy this book
- About this book
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Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls.
Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
- Reviews
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From the reviews:
“This volume forms part of the Springer Protocols ‘Methods in Molecular Biology’ series … . All the chapters are quite well written, being concise and clearly laid out. … In conclusion, this is a useful laboratory professional’s ‘workshop manual’ for the most well-established immunotoxicity assays, focusing very much on the procedures at the laboratory bench. It will be a useful basic source of information for anyone starting to establish some of the test methods in their own laboratory.” (Peter R. Ryle, BTS Newsletter, Issue 37, Winter, 2010)
“In this book, Dr. Dietert of Cornell University has done an excellent job in covering concepts of immunotoxicology associated with analytical approaches to investigate mechanisms of toxicity and for the diagnosis of poisoning. Through very well-devised and illustrated texts by renowned researchers in immunotoxicology, the 26 chapters of this book cover the vast literature on approaches and strategies for immunotoxic testing, with detailed laboratory protocols. Thus, the book serves as a reference source for students, laboratory technicians and scientific researchers in toxicology.” (Sandra Farsky, Brazilian Journal of Pharmaceutical Sciences, May, 2010)
“This book provides a collection of testing approaches and strategies with detailed laboratory protocols in the successful style of the Methods in Molecular Biology series. … audience includes not only scientists working directly in the field of immunotoxicology, but also students, technicians, and lab and safety office personnel. … meant to be used by a specific subgroup of immunologists, the protocols are also used in many laboratory situations and are not limited to immunotoxicity studies. … The book appears to fill an important niche.” (Marion C. Cohen, Doody’s Review Service, September, 2010)
- Table of contents (26 chapters)
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Immunotoxicology Testing: Past and Future
Pages 3-13
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Developmental Immunotoxicity (DIT): The Why, When, and How of DIT Testing
Pages 17-25
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An In Vivo Tiered Approach to Test Immunosensitization by Low Molecular Weight Compounds
Pages 27-37
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Risk of Autoimmune Disease: Challenges for Immunotoxicity Testing
Pages 39-51
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Markers of Inflammation
Pages 53-73
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Table of contents (26 chapters)
Bibliographic Information
- Bibliographic Information
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- Book Title
- Immunotoxicity Testing
- Book Subtitle
- Methods and Protocols
- Editors
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- Rodney R. Dietert
- Series Title
- Methods in Molecular Biology
- Series Volume
- 598
- Copyright
- 2010
- Publisher
- Humana Press
- Copyright Holder
- Humana Press
- eBook ISBN
- 978-1-60761-401-2
- DOI
- 10.1007/978-1-60761-401-2
- Hardcover ISBN
- 978-1-60761-400-5
- Softcover ISBN
- 978-1-4939-5731-6
- Series ISSN
- 1064-3745
- Edition Number
- 1
- Number of Pages
- X, 430
- Topics
