Overview
- Broadens the reader’s understanding of host-pathogen interactions regarding Helicobacter pylori
- Provides new insights into the context of gastric inflammation and carcinogenesis
- Reviews the impact of H. pylori virulence factors on the host’s immune system
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 421)
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Table of contents (13 chapters)
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Front Matter
Keywords
About this book
This book focuses on immune reactions and interactions of humans with Helicobacter pylori - a human pathogen connected to gastritis, peptic ulcers and even gastric cancer. With nearly half of the world’s population colonized, it has been characterized as one of the most successful pathogens for more than 100,000 years of co-evolution with its host. The respective chapters discuss not only how H. pylori infection is considered a paradigm for persistent bacterial infection and chronic inflammation, but also how the infection might be connected to host protection against gastro-esophageal diseases, asthma, and other allergic disease manifestations. Readers will gain essential insights into the roles of specific factors in the immune response and learn about the impact of genetic polymorphisms on the risk of gastric carcinogenesis. In addition, the book discusses the strategies used by this bacterium, which allow it to colonize specific sites in the stomach, interact with the microbiome, evade immune surveillance and undermine the resolution of inflammation during persistent infection.
This volume presents a concise summary of recent advances in the areas of induction, resolution and escape of inflammation, innate and adaptive immunity, gastric disease development, as well as treatment and vaccination against H. pylori. Accordingly, it offers a valuable asset for scientists and clinicians alike.
Editors and Affiliations
About the editor
Chair of Microbiology
Friedrich Alexander University Erlangen/Nuremberg
Department of Biology
Division of Microbiology
Staudtstr. 5
D-91058 Erlangen
Germany
Tel. ++49 9131 8528081
Fax ++49 9131 8528082
Bibliographic Information
Book Title: Molecular Mechanisms of Inflammation: Induction, Resolution and Escape by Helicobacter pylori
Editors: Steffen Backert
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-030-15138-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Switzerland AG 2019
Hardcover ISBN: 978-3-030-15137-9Published: 05 June 2019
Softcover ISBN: 978-3-030-15140-9Published: 14 August 2020
eBook ISBN: 978-3-030-15138-6Published: 23 May 2019
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: XXIV, 359
Number of Illustrations: 1 b/w illustrations, 28 illustrations in colour
Topics: Immunology, Medical Microbiology, Gastroenterology, Human Physiology