Advances in Experimental Medicine and Biology

Polymyxin Antibiotics: From Laboratory Bench to Bedside

Editors: Li, Jian, Nation, Roger L., Kaye, Keith (Eds.)

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  • Provides a comprehensive review on pharmacokinetics, pharmacodynamics and toxicity of polymyxins 
  • Clarifies the confusing definitions of potency of colistin used in different parts of the world
  • Reviews strategies of discovery of novel polymyxin-like antibiotics
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eBook $149.00
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  • ISBN 978-3-030-16373-0
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Hardcover $199.99
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About this book

This volume is the first-ever complete treatise on polymyxins and presents the most comprehensive and up-to-date reviews of all major research and clinical topics from chemistry, microbiology, pharmacology, clinical use, to drug discovery. All chapters were written by internationally leading researchers and clinicians in the field.

It is our wish that readers discover the importance of polymyxin structure in relation to the mechanisms of activity, resistance and toxicity. We emphasized that reliable analytic methods for polymyxins are critical when investigating their pharmacokinetics (PK) and pharmacodynamics (PD). The complicated dose definitions and different pharmacopoeial standards have already compromised the safe use of polymyxins in patients. Therefore, informed by the latest pharmacological information, scientifically-based dosing recommendations have been proposed for intravenous polymyxins. Considering the PK/PD limitations and potential development of resistance, polymyxin combinations are encouraged; however, the current literature has not shown definite microbiological benefits, possibly because most clinical studies to date overlooked key PK/PD principles. Nephrotoxicity is the major dose-limiting factor and it is imperative to elucidate the mechanisms and develop novel approaches to minimize polymyxin-associated toxicities. In addition, the anti-endotoxin effect of polymyxins supports their clinical use to treat Gram-negative sepsis. Fortunately, the discovery of new-generation polymyxins with wider therapeutic windows has benefited from the latest achievements in polymyxin research.

This book provides extensive pharmacological information on polymyxins to infectious diseases clinicians, pharmacists, clinical microbiologists, antimicrobial pharmacologists, and pharmaceutical scientists, and is an essential read for those who aim to develop novel polymyxins and improve their clinical use as a last-line defense against Gram-negative ‘superbugs’. 

Table of contents (21 chapters)

Table of contents (21 chapters)

Buy this book

eBook $149.00
price for USA
  • ISBN 978-3-030-16373-0
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $199.99
price for USA

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Bibliographic Information

Bibliographic Information
Book Title
Polymyxin Antibiotics: From Laboratory Bench to Bedside
Editors
  • Jian Li
  • Roger L. Nation
  • Keith Kaye
Series Title
Advances in Experimental Medicine and Biology
Series Volume
1145
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-16373-0
DOI
10.1007/978-3-030-16373-0
Hardcover ISBN
978-3-030-16371-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 366
Number of Illustrations
45 b/w illustrations, 44 illustrations in colour
Topics