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Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Focus on Migraine

  • Book
  • © 2019

Overview

Editors:
  1. Susan D. Brain

    1. School of Cardiovascular Medicine & Sciences, King’s College London, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. Pierangelo Geppetti

    1. Department of Health Sciences, University of Florence, Florence, Italy

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a thorough review of the key recent research into the role of CGRP in health and disease
  • Enables and enriches understanding of CGRP in migraine pathophysiology
  • Provides a full update of the latest therapeutic perspectives and clinical advancements with potential therapeutic agents that block the actions of CGRP

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 255)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-vii
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  2. CGRP Discovery and Timeline

    • Kate Arkless, Fulye Argunhan, Susan D. Brain
    Pages 1-12

  3. CGRP Receptor Biology: Is There More Than One Receptor?

    • Debbie L. Hay
    Pages 13-22

  4. The Structure of the CGRP and Related Receptors

    • John Simms, Sarah Routledge, Romez Uddin, David Poyner
    Pages 23-36

  5. CGRP Receptor Signalling Pathways

    • Graeme S. Cottrell
    Pages 37-64

  6. Pathways of CGRP Release from Primary Sensory Neurons

    • Francesco De Logu, Romina Nassini, Lorenzo Landini, Pierangelo Geppetti
    Pages 65-84

  7. CGRP in Animal Models of Migraine

    • Anne-Sophie Wattiez, Mengya Wang, Andrew F. Russo
    Pages 85-107

  8. CGRP in Human Models of Migraine

    • Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
    Pages 109-120

  9. Role of CGRP in Migraine

    • Lars Edvinsson
    Pages 121-130

  10. Understanding CGRP and Cardiovascular Risk

    • Eloísa Rubio-Beltrán, Antoinette Maassen van den Brink
    Pages 131-140

  11. CGRP and Painful Pathologies Other than Headache

    • David A. Walsh, Daniel F. McWilliams
    Pages 141-167

  12. Calcitonin Gene-Related Peptide Antagonists and Therapeutic Antibodies

    • Roxana-Maria Rujan, Christopher A. Reynolds
    Pages 169-192
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Keywords

About this book

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine.  The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. 

Editors and Affiliations

  • School of Cardiovascular Medicine & Sciences, King’s College London, London, UK

    Susan D. Brain

  • Department of Health Sciences, University of Florence, Florence, Italy

    Pierangelo Geppetti

Bibliographic Information

  • Book Title: Calcitonin Gene-Related Peptide (CGRP) Mechanisms

  • Book Subtitle: Focus on Migraine

  • Editors: Susan D. Brain, Pierangelo Geppetti

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-030-21454-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Hardcover ISBN: 978-3-030-21453-1Published: 11 September 2019

  • Softcover ISBN: 978-3-030-21456-2Published: 11 September 2020

  • eBook ISBN: 978-3-030-21454-8Published: 31 August 2019

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: VII, 192

  • Number of Illustrations: 6 b/w illustrations, 17 illustrations in colour

  • Topics: Pharmacology/Toxicology, Neurology, Pain Medicine, Neurosciences

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