Advances in Microbiology, Infectious Diseases and Public Health

Pertussis Infection and Vaccines

Advances in Microbiology, Infectious Diseases and Public Health Volume 12

Editors: Fedele, Giorgio, Ausiello, Clara Maria (Eds.)

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  • Offers a comprehensive overview of the research on pertussis infection and vaccination  
  • Discusses pertussis prevention, control and clinical management
  • Highlights the latest vaccination strategies and novel vaccines
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  • ISBN 978-3-030-33249-5
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About this book

This book provides a comprehensive overview of pertussis - also known as whooping cough. The first part discusses the evolution the genus Bordetellae and the molecular epidemiology of B. pertussis, while the following chapters focus on the role of B. pertussis virulence factors in infection and disease and on the mechanisms of the immune response to infection and vaccination. The book also explores the prevention and control of the disease as well as its clinical management, with the finally section addressing vaccination, from improved immunization strategies to novel vaccines.

Pertussis remains one of the most poorly controlled vaccine-preventable diseases around the globe. Universal vaccination has dramatically reduced its incidence but has failed to bring it completely under control. In recent decades, changes in pertussis epidemiology have been noted, likely related to the use of acellular pertussis vaccines, which in many countries have replaced older-generation, whole-cell pertussis vaccines. Several years after their introduction, it is becoming apparent that immunity conferred by acellular vaccines wanes more rapidly than expected. Unlike whole-cell vaccines, acellular vaccines, while protecting against the disease, do not seem to prevent colonization and transmission. Increasing incidence among adolescents and adults makes them a reservoir for transmission to unimmunized infants, who in turn are at risk of severe disease and death.

This book is a valuable resource for researchers and clinicians in the field of medical microbiology, vaccine research and infectious diseases.

About the authors

Dr. Giorgio Fedele

Istituto Superiore di Sanità

Roma, Italy

Email : giorgio.fedele@iss.it

 

Dr. Clara Maria Ausiello

Roma, Italy

Email : clara.ausiello@gmail.com


Table of contents (11 chapters)

Table of contents (11 chapters)
  • How Genomics Is Changing What We Know About the Evolution and Genome of Bordetella pertussis

    Pages 1-17

    Ring, Natalie (et al.)

  • Molecular Epidemiology of Bordetella pertussis

    Pages 19-33

    Barkoff, Alex-Mikael (et al.)

  • Role of Major Toxin Virulence Factors in Pertussis Infection and Disease Pathogenesis

    Pages 35-51

    Scanlon, Karen (et al.)

  • Functional Programming of Innate Immune Cells in Response to Bordetella pertussis Infection and Vaccination

    Pages 53-80

    Gillard, Joshua (et al.)

  • Superior B. pertussis Specific CD4+ T-Cell Immunity Imprinted by Natural Infection

    Pages 81-98

    Lambert, Eleonora E. (et al.)

Buy this book

eBook $139.00
price for USA
  • ISBN 978-3-030-33249-5
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $179.99
price for USA

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Bibliographic Information

Bibliographic Information
Book Title
Pertussis Infection and Vaccines
Book Subtitle
Advances in Microbiology, Infectious Diseases and Public Health Volume 12
Editors
  • Giorgio Fedele
  • Clara Maria Ausiello
Series Title
Advances in Microbiology, Infectious Diseases and Public Health
Series Volume
1183
Copyright
2019
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-33249-5
DOI
10.1007/978-3-030-33249-5
Hardcover ISBN
978-3-030-33248-8
Series ISSN
2365-2675
Edition Number
1
Number of Pages
VIII, 170
Number of Illustrations
10 illustrations in colour
Topics