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Interaction of Nanomaterials with the Immune System

  • Book
  • © 2020

Overview

Editors:
  1. James C. Bonner

    1. Department of Biological Sciences, North Carolina State University, Raleigh, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Jared M. Brown

    1. Department of Pharmaceutical Sciences Skaggs School of Pharmacy, University of Colorado, Aurora, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive, up-to-date information on the current knowledge of immune responses to ENMs
  • Testing strategies for evaluating immunotoxicity of ENMs
  • Alternative methods of testing including in vitro high throughput and computational methods
  • Authors are leaders in the field of Nanotoxicology and span several different continents

Part of the book series: Molecular and Integrative Toxicology (MOLECUL)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Introduction

    • James C. Bonner, Jared M. Brown
    Pages 1-14

  3. Macrophages: First Innate Immune Responders to Nanomaterials

    • Dorothy J. You, Ho Young Lee, James C. Bonner
    Pages 15-34

  4. Nanomaterials and Neutrophils

    • Sandeep Keshavan, Bengt Fadeel
    Pages 35-53

  5. Mast Cells and Nanomaterials

    • Ryan P. Mendoza, Jared M. Brown
    Pages 55-72

  6. Impact of Nanoparticles on Dendritic Cells

    • Rob J. Vandebriel, Henk van Loveren
    Pages 73-82

  7. Complement Activation by Nanomaterials

    • Dmitri Simberg, Seyed M. Moghimi
    Pages 83-98

  8. Translocation, Biodistribution, and Fate of Nanomaterials in the Body

    • Melisa Bunderson-Schelvan, Andrij Holian, Kevin L. Trout, Raymond F. Hamilton
    Pages 99-125

  9. Oxidative Stress and Redox Modifications in Nanomaterial–Cellular Interactions

    • Tong Zhang, Matthew J. Gaffrey, Wei-Jun Qian, Brian D. Thrall
    Pages 127-148

  10. Allergy and Immunity Induced by Nanomaterials

    • Harri Alenius, Kai Savolainen
    Pages 149-165

  11. Nanomaterial Effects on Viral Infection

    • Hao Chen, Sara T. Humes, Navid B. Saleh, John A. Lednicky, Tara Sabo-Attwood
    Pages 167-195

  12. Immunotoxicity Testing – In Vitro Cell Culture Models

    • Barbara Rothen-Rutishauser, Barbara Drasler, Alke Petri-Fink
    Pages 197-215

  13. Back Matter

    Pages 217-223
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Keywords

About this book

This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.   

Editors and Affiliations

  • Department of Biological Sciences, North Carolina State University, Raleigh, USA

    James C. Bonner

  • Department of Pharmaceutical Sciences Skaggs School of Pharmacy, University of Colorado, Aurora, USA

    Jared M. Brown

About the editors

James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models. 

Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.


Bibliographic Information

  • Book Title: Interaction of Nanomaterials with the Immune System

  • Editors: James C. Bonner, Jared M. Brown

  • Series Title: Molecular and Integrative Toxicology

  • DOI: https://doi.org/10.1007/978-3-030-33962-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-33961-6Published: 31 January 2020

  • Softcover ISBN: 978-3-030-33964-7Published: 31 January 2021

  • eBook ISBN: 978-3-030-33962-3Published: 30 January 2020

  • Series ISSN: 2168-4219

  • Series E-ISSN: 2168-4235

  • Edition Number: 1

  • Number of Pages: X, 223

  • Number of Illustrations: 11 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmacology/Toxicology, Immunology, Nanotechnology

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