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Morphogenesis, Environmental Stress and Reverse Evolution

  • Gives a unique perspective on the role of stress in evolution which spans the entirety of biology, from unicellular to multicellular, invertebrate to vertebrate
  • Elaborates on the premise that the environment has a stressful impact on all living organisms, causing the latter to evolve in reciprocation with the environment, or face extinction
  • Advances the emerging concept of niche construction as the main process of reciprocation between biology and the environment
  • Offers empirical evidence for the feasibility of 'reverse evolution', a possibility denied by conventional Darwinian evolution

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-vi
  2. Introduction

    • Jean Guex
    Pages 1-11
  3. Stress-Related Evolution in Triassic Conodonts and the Middle Norian Juvenile Mortality

    • Viktor Karádi, Attila Virág, Tea Kolar-Jurkovšek, Bogdan Jurkovšek
    Pages 37-58
  4. Proteromorphosis in Early Triassic Conodonts

    • Ali Murat Kiliç, Jean Guex, Francis Hirsch
    Pages 59-96
  5. Developmental Plasticity Induced by Either External or Internal Environment Co-opts Ancient Regulatory Networks

    • Juan Nicolas Malagon, Sam Scanga, Ernest Ho, Armen Manoukian, Ellen Larsen
    Pages 97-109
  6. Extreme Morphological Plasticity Within Orbulina-“Praeorbulina-Like” Assemblages Related to Environmental Stress

    • Ahmed Belhadji, Annachiara Bartolini, Linda Rossignol, Lahcène Belkebir, Jean Guex
    Pages 111-127
  7. Morphological Deformation of Foraminiferal Tests Caused by Intertidal Oil Spills (Black Tides)

    • Marie-Thérèse Vénec-Peyré, Annachiara Bartolini, Michele Weber, Jere H. Lipps
    Pages 175-196
  8. Environmental Control on Biotic Development in Siberia (Verkhoyansk Region) and Neighbouring Areas During Permian–Triassic Large Igneous Province Activity

    • Yuri D. Zakharov, Alexander S. Biakov, Micha Horacek, Ruslan V. Kutygin, Evgeny S. Sobolev, David P. G. Bond
    Pages 197-231
  9. Stress, Development, and Evolution in Coral Reef Communities

    • Neil W. Blackstone, Austin P. Parrin
    Pages 233-244
  10. Evolution as a Timeless Continuum

    • John S. Torday, William B. Miller Jr.
    Pages 289-297
  11. Chronic Disease as Reverse Evolution

    • John S. Torday, William B. Miller Jr.
    Pages 299-309
  12. Back Matter

    Pages 311-322

About this book

It is widely acknowledged that life has adapted to its environment, but the precise mechanism remains unknown since Natural Selection, Descent with Modification and Survival of the Fittest are metaphors that cannot be scientifically tested. In this unique text, invertebrate and vertebrate biologists illuminate the effects of physiologic stress on epigenetic responses in the process of evolutionary adaptation from unicellular organisms to invertebrates and vertebrates, respectively. This book offers a novel perspective on the mechanisms underlying evolution.

Capacities for morphologic alterations and epigenetic adaptations subject to environmental stresses are demonstrated in both unicellular and multicellular organisms. Furthermore, the underlying cellular-molecular mechanisms that mediate stress for adaptation will be elucidated wherever possible. These include examples of ‘reverse evolution’ by Professor Guex for Ammonites and for mammals by Professor Torday and Dr. Miller. This provides empiric evidence that the conventional way of thinking about evolution as unidirectional is incorrect, leaving open the possibility that it is determined by cell-cell interactions, not sexual selection and reproductive strategy. Rather, the process of evolution can be productively traced through the conservation of an identifiable set of First Principles of Physiology that began with the unicellular form and have been consistently maintained, as reflected by the return to the unicellular state over the course of the life cycle.

Editors and Affiliations

  • Institute of Earth Sciences, Geopolis, UNIL, Lausanne, Switzerland

    Jean Guex

  • Department of Pediatrics, Obstetrics and Gynecology, Evolutionary Medicine Program, David Geffen School of Medicine, University of California, Los Angeles, USA

    John S. Torday

  • Department of Medicine, Banner Health System, Paradise Valley, USA

    William B. Miller Jr.

About the editors

Professor Guex has published Retrograde Evolution During Major Extinction Crises (Springer, 2016), which forms the basis for the invertebrate examples used in this book.


John S. Torday, PhD, is a Professor on the Faculty of the Evolutionary Medicine Program at UCLA. He received his Bachelor of Arts degree from Boston University (1968), a Master of Science degree from McGill University (1971), a Doctor of Philosophy degree from McGill University (1974), and did post-doctoral training in Reproductive Medicine at the University of Wisconsin-Madison (1974-76).  He was previously on the Faculties of Harvard Medical School (1976-91) and the University of Maryland Medical School (1991-98). He has authored more than 100 peer-reviewed articles and 5 monographs on the subject of cellular-molecular evolution.



William B. Miller Jr. MD. attended the Honors Program in Medicine at NorthwesternUniversity, graduating with a B.S. In Medicine (1973) and a Doctor of Medicine (1975). He is a member of the medical honors society, Alpha Omega Alpha. Dr. Miller was a practicing physician for 35 years. During that period, he publishing a number of  academic medical articles. A series of observations about the patterns of infectious disease made based on active medical practice spurred an interest in genetics, evolutionary biology and the microbiome and  ultimately led to the publication of The Microcosm Within: Evolution and Extinction in the Hologenome (2013). More than two dozen peer-reviewed academic articles on evolution and the microbiome and several more books on those topics as co-author and co-editor have followed.

Bibliographic Information

  • Book Title: Morphogenesis, Environmental Stress and Reverse Evolution

  • Editors: Jean Guex, John S. Torday, William B. Miller Jr.

  • DOI: https://doi.org/10.1007/978-3-030-47279-5

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Switzerland AG 2020

  • Hardcover ISBN: 978-3-030-47278-8Published: 24 July 2020

  • Softcover ISBN: 978-3-030-47281-8Published: 25 July 2021

  • eBook ISBN: 978-3-030-47279-5Published: 23 July 2020

  • Edition Number: 1

  • Number of Pages: VI, 322

  • Number of Illustrations: 65 b/w illustrations, 40 illustrations in colour

  • Topics: Evolutionary Biology, Biodiversity, Paleontology, Microbiology, Invertebrates

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access