Editors:
- Offers a much more comprehensive second edition with several new chapters on various ion channels
- Builds a bridge between historical fundamentals and the latest advances in ion channel research
- Provides insights and methods from leading laboratories around the world
Part of the book series: Physiology in Health and Disease (PIHD)
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Table of contents (13 chapters)
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Front Matter
About this book
This volume focuses on basic fundamentals of epithelial transport physiology. There is a range of chapters dedicated to specific aspects of epithelial ion transport and cell function. Accordingly, the authors discuss techniques used to determine epithelial function, principles of epithelia transport, polarization of epithelial cells, mathematical modelling of epithelial ion transport, protein folding of ion channels, degradation epithelial ion channels, fundamentals of epithelial sodium, potassium and chloride transport, fundamentals of bicarbonate secretion, volume regulation, and microRNA regulation of epithelial channels and transporters. Given its scope, Volume 1 offers a valuable resource for physiology students, scientists and clinicians alike.
Editors and Affiliations
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Department of Physiology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand
Kirk L. Hamilton
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Department of Cell Biology, University of Pittsburgh, Pittsburgh, USA
Daniel C. Devor
About the editors
Kirk L. Hamilton was born in Baltimore, Maryland in 1953. He gained his undergraduate (biology/chemistry) and M.Sc. (ecology) degrees from the University of Texas at Arlington. He obtained his Ph.D. at Utah State University under the tutelage of Dr. James A. Gessaman, where he studied incubation physiology of Barn owls. His first post-doctoral position was at the University of Texas Medical Branch in Galveston, Texas under the mentorship of Dr. Douglas C. Eaton where he studied epithelial ion transport, specifically, the epithelial sodium channel (ENaC). He then moved to the Department of Physiology at the University of Alabama, Birmingham for additional post-doctoral training under the supervision of the late Dr. Dale J. Benos where he further studied ENaC, and non-specific cation channels. He took his first academic post in the Department of Biology at Xavier University of Louisiana in New Orleans (1990-1994). He then joined the Department of Physiology at the University of Otago in 1994, and he is currently an Associate Professor. He has focused his research on the molecular physiology and trafficking of potassium channels (specifically KCa3.1). He has published more than 60 papers and book chapters. His research work has been funded by the NIH, American Heart Association, Cystic Fibrosis Foundation, and Lottery Health Board New Zealand. Dr. Devor and he have been collaborators since 1999. When he not working, he enjoys playing guitar (blues and jazz) and volleyball. Kirk is married to Judith Rodda, a recent Ph.D. graduate in spatial ecology. They have 2 children, Nathan (b. 1995) and Emma (b. 1998).
Daniel C. Devor was born in Vandercook Lake, Michigan in 1961. His education took him through Southampton College of Long Island University, where he studied Marine Biology, before entering SUNY Buffalo for his Ph.D., under the guidance of Dr. Michael E. Duffey. During this time, he studied the role of basolateral potassium channels inregulating transepithelial ion transport. He subsequently did his post-doctoral work at the University of Alabama, Birmingham, under the mentorship of Dr. Raymond A. Frizzell, where he studied both apical CFTR and basolateral KCa3.1 in intestinal and airway epithelia. He joined the University of Pittsburgh faculty in 1995 where he is currently a Professor of Cell Biology. During this time, he has continued to study the regulation, gating and trafficking of KCa3.1 as well as the related family member, KCa2.3, publishing more than 50 papers on these topics. These studies have been funded by the NIH, Cystic Fibrosis Foundation, American Heart Association and pharmaceutical industry. When not in the lab, he enjoys photography and growing exotic plants. Dan is married to Catherine Seluga, an elementary school teacher. They have 3 children, Caitlin (b. 1990), Emily (b. 1993) and Daniel (b. 1997).Bibliographic Information
Book Title: Basic Epithelial Ion Transport Principles and Function
Book Subtitle: Ion Channels and Transporters of Epithelia in Health and Disease - Vol. 1
Editors: Kirk L. Hamilton, Daniel C. Devor
Series Title: Physiology in Health and Disease
DOI: https://doi.org/10.1007/978-3-030-52780-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The American Physiological Society 2020
Hardcover ISBN: 978-3-030-52779-2Published: 27 November 2020
Softcover ISBN: 978-3-030-52782-2Published: 27 November 2021
eBook ISBN: 978-3-030-52780-8Published: 26 November 2020
Series ISSN: 2625-252X
Series E-ISSN: 2625-2538
Edition Number: 2
Number of Pages: XIX, 563
Number of Illustrations: 35 b/w illustrations, 71 illustrations in colour
Topics: Human Physiology, Molecular Medicine, Protein Science, Membrane Biology