Locoregional Radionuclide Cancer Therapy

Clinical and Scientific Aspects

Editors: Wong, Franklin C.L. (Ed.)

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  • Offers a comprehensive review of locoregional radionuclide cancer therapies (LRCT)
  • Includes updated scientific modeling and imaging algorithms
  • Written by experts
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  • ISBN 978-3-030-56267-0
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About this book

This book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.

Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.

This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.


About the authors

Franklin C. L. Wong

University of Texas

MD Anderson Cancer Center

Houston, TX

USA


Table of contents (11 chapters)

Table of contents (11 chapters)
  • Human Cancer: Epidemiology, Hallmarks, and Defense Strategies

    Pages 1-15

    Wong, Brian S. (et al.)

  • Cancer Treatment Modalities Systemic and Locoregional Approaches: Challenges and Opportunities of Multidisciplinary Approaches

    Pages 17-37

    Pestana, Roberto Carmagnani (et al.)

  • Cancer Radiotherapy: General Considerations and Human Radiobiology

    Pages 39-59

    Yoder, Alison K. (et al.)

  • Radionuclide Cancer Therapy: Unsealed Alpha- and Beta-Emitters

    Pages 61-87

    Civelek, A. Cahid (et al.)

  • Locoregional Therapy: Cancer Interventions with and Without Radionuclides

    Pages 89-109

    Yevich, Steven (et al.)

Buy this book

eBook $129.00
price for USA
  • ISBN 978-3-030-56267-0
  • Digitally watermarked, DRM-free
  • Included format: EPUB, PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Hardcover $169.99
price for USA

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Bibliographic Information

Bibliographic Information
Book Title
Locoregional Radionuclide Cancer Therapy
Book Subtitle
Clinical and Scientific Aspects
Editors
  • Franklin C.L. Wong
Copyright
2021
Publisher
Springer International Publishing
Copyright Holder
Springer Nature Switzerland AG
eBook ISBN
978-3-030-56267-0
DOI
10.1007/978-3-030-56267-0
Hardcover ISBN
978-3-030-56266-3
Edition Number
1
Number of Pages
XII, 268
Number of Illustrations
20 b/w illustrations, 56 illustrations in colour
Topics