Authors:
- Great compendium of biosensor development and their mathematical modeling
- Presents unique modeling methods for a wide range of biosensors
- Builds on success of earlier edition, offering new insights on optimal design of biosensors
Part of the book series: Springer Series on Chemical Sensors and Biosensors (SSSENSORS, volume 9)
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Table of contents (13 chapters)
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Front Matter
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Back Matter
About this book
This newly designed and enlarged edition offers an up-to-date presentation of biosensor development and modeling from both a chemical and a mathematical point of view. An entire new chapter in particular is dedicated to optimal design of biosensors. Two more new chapters discuss biosensors which utilize microbial cells and are based on carbon nanotubes respectively. All the other chapters have been revised and updated.
The book contains unique modeling methods for amperometric, potentiometric and optical biosensors based mainly on biocatalysts . It examines processes that occur in the sensors' layers and at their interface, and it provides analytical and numerical methods to solve equations of conjugated enzymatic (chemical) and diffusion processes. The action of single enzyme as well as polyenzyme biosensors and biosensors based on chemically modified electrodes is studied. The modeling of biosensors that contain perforated membranes and multipart mass transport profiles is critically investigated. Furthermore, it is fully described how signals can be biochemically amplified, how cascades of enzymatic substrate conversion are triggered, and how signals are processed via a chemometric approach and artificial neuronal networks. The results of digital modeling are compared with both proximal analytical solutions and experimental data.
Keywords
- carbon nanotube based biosensors
- optimal design of biosensors
- Enzymatic Kinetic
- Nernst diffusion layer
- bi-enzyme biosensors
- microbial cells
- consecutive substrates conversion
- parallel substrates conversion
- cyclic substrates conversion
- synergistic substrates conversion
- glucose dehydrogenase-based biosensor
- chemically modified electrodes
- perforated membranes
- Non Michaelis–Menten Enzyme
- heterogeneous microreactor
- Metabolite biosensor
- bioluminescent biosensor
- BOD biosensor
- chemically modified electrodes
- allosteric enzyme layer
Authors and Affiliations
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Faculty of Mathematics & Informatics Institute of Computer Science, Vilnius University, Vilnius, Lithuania
Romas Baronas, Feliksas Ivanauskas
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Life Sciences Center, Vilnius University, Vilnius, Lithuania
Juozas Kulys
About the authors
Feliksas Ivanauskas is a Professor Emeritus of the Vilnius University (Lithuania). He joint this university in 1972 as Senior Lecturer, and later on, as Associate Professor, Professor, Head of the Department of Mathematical Software, Head of the Department of Differential Equations and Numerical Mathematics, Head of the Department of Computer Science II, and Dean ofFaculty of Mathematics and Informatics.
He received his Ph.D. in Mathematics from the Moscow State University and the second degree (Habilitation Doctor) in Mathematics from the Institute of Mathematical Modeling, Russia AS (Moscow), in 1974 and 1992, respectively. He has published 250+ scientific articles and holds two patents on solid-state sources of light. Prof. Ivanauskas received the Lithuanian National Prizes in Science 1995 and 2010. He was Chair of the Division of Mathematical, Physical and Chemical Sciences of Lithuanian Academy of Science from 2009 until 2017.
Juozas Kulys is a Professor Emeritus of the Life Sciences Center of Vilnius University (Lithuania), and his main scientific interests focus on chemical problems of biocatalysis, biosensors development and modeling. He received his Ph.D. from the M. V. Lomonosov Moscow State University (Russia) in 1970, and the second degree (Habilitation Doctor) at the N. N. Semenov Chemical Physics Institute in1982. In 1984 he was assessed as Professor of Physical Chemistry, and worked as Senior Research Associate, Head of the Department of Enzyme Chemistry (1974-2016) and as a Director (1986-1992) of the Institute of Biochemistry of Vilnius University (Lithuania). From 2001 until 2018 he was also the Head of the Department and professor of Chemistry and Bioengineering of Vilnius Gediminas Technical University (Lithuania). He was awarded the State Science Prize (1987), the Baltic Assembly Premium of Science (1995), National Science Premium (2002), and he was elected as a member of the Lithuania Academy of Sciences (1990).
Bibliographic Information
Book Title: Mathematical Modeling of Biosensors
Authors: Romas Baronas, Feliksas Ivanauskas, Juozas Kulys
Series Title: Springer Series on Chemical Sensors and Biosensors
DOI: https://doi.org/10.1007/978-3-030-65505-1
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer Nature Switzerland AG 2021
Hardcover ISBN: 978-3-030-65504-4Published: 16 February 2021
Softcover ISBN: 978-3-030-65507-5Published: 17 February 2022
eBook ISBN: 978-3-030-65505-1Published: 15 February 2021
Series ISSN: 1612-7617
Edition Number: 2
Number of Pages: XVII, 456
Number of Illustrations: 140 b/w illustrations, 12 illustrations in colour
Topics: Biomedical Engineering and Bioengineering, Biochemical Engineering, Math. Applications in Chemistry, Theoretical, Mathematical and Computational Physics, Food Science, Applications of Mathematics