Cellular and Biochemical Mechanisms of Obesity

1. Front Matter

   Pages i-xviii

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2. Pathophysiologic Mechanisms of Obesity

   1. Front Matter

      Pages 1-1

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   2. Obesity as a Major Health Hazard

      • Paramjit S. Tappia, Naranjan S. Dhalla

      Pages 3-21

   3. Endocrine Role of Adipose Tissue in Obesity and Related Disorders

      • Shravanthi S. Kumar, Alok Kumar Mishra, Asit Ranjan Ghosh

      Pages 23-42

   4. Interaction Between Genetics and Epigenetics in Obesity and Their Clinical Significance

      • Zahra Sepehri, Mahsa Motavaf, Aliyeh Sargazi, Zohre Kiani, Mehdi Sepehri, Moayed S. Alavian

      Pages 43-86

   5. The Epigenetics and Molecular Interplay in Obesity and Associated Complications

      • Hitesh Soni, Seema Dangwal

      Pages 87-104

   6. Cellular and Biochemical Mechanisms Driving the Susceptibility of Obese Subjects to Covid-19 Infection

      • Manal M. Smail, Jaipaul Singh, Abla Mohammed Ismail, Emanuel Cummings, Carlin Hanoman, Sunil Rupee et al.

      Pages 105-118

   7. Dysfunctional Circadian Rhythm Is Associated with Food Consumption, Obesity and Related Metabolic Diseases: Role of Ion Channels

      • A. Cihangir Uguz, Lourdes Franco Hernandez, Jaipaul Singh, Ana Beatriz Rodriguez Moratinos, Jose Antonio Pariente Llanos

      Pages 119-155

   8. Hypothalamus-Mediated Actions in the Genesis of Obesity

      • Matthew Ramjiawan, Paramjit S. Tappia

      Pages 157-166

   9. Cellular and Molecular Effects of Obesity on the Heart

      • Ahmed Sultan, Jaipaul Singh, Frank Christopher Howarth

      Pages 167-183

   10. Dietary Advanced Glycation End Products as Mediators of Obesity: Cellular and Molecular Mechanisms of Action

       • Chinedum Ogbonnaya Eleazu, Victor Udo Nna, Joseph Bagi Suleiman, Mahaneem Mohamed

       Pages 185-197

   11. Monoamine Oxidase, Obesity and Related Comorbidities: Discovering Bonds

       • Adrian Sturza, Danina M. Muntean, Octavian M. Crețu

       Pages 199-213

   12. Adipose Extracellular Matrix Remodeling in Obesity and Insulin Resistance

       • Francisco Javier Ruiz-Ojeda, Julio Plaza-Díaz, Augusto Anguita-Ruiz, Andrea Méndez-Gutiérrez, Concepción María Aguilera

       Pages 215-229

3. Therapeutic Mechanisms of Obesity

   1. Front Matter

      Pages 231-231

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   2. Obesity; Its Prevalence, Consequences and Potential Therapies

      • Tanya Sharma, Husam Salah, Naga Sai Shravan Turaga, Jawahar L. Mehta

      Pages 233-248

   3. Obesity: Molecular Mechanisms, Epidemiology, Complications and Pharmacotherapy

      • Saeeda Al Jaberi, Athena Cohen, Zulqarnain Saeed, Shreesh Ojha, Jaipaul Singh, Ernest Adeghate

      Pages 249-266

   4. Telomere Shortening and Calorie Restriction in Obesity

      • Naoki Makino, Toyoki Maeda

      Pages 267-279

   5. Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions

      • Anureet K. Shah, Naranjan S. Dhalla

      Pages 281-296

   6. The Relevance of Metabotrophic Factors in Pathobiology and Therapy of Obesity and Related Diseases

      • George N. Chaldakov, Luigi Aloe, Gorana Rancic, Rouzha Z. Pancheva, Marcia Hiriart, Marco Fiore et al.

      Pages 297-312

   7. New Therapeutic Agents in Obesity-Related Cardiovascular Disorders: Molecular and Cellular Insights

      • Belma Turan, Deniz Billur

      Pages 313-335

Global health has been challenged with the dawning of the era of the obesity epidemic, and thus as a consequence, strategies to reduce obesity have become public health priorities. According to the United Nations, obesity has been identified as a concern for achieving Sustainable Development Goals. Obesity is a serious health problem with an increased risk of several common diseases including diabetes, cardiovascular disease, and cancer. Although the fundamental cause of obesity and overweight is an imbalance between calorie intake and calorie expenditure, the underlying biochemical and metabolic processes that cause obesity are not fully understood.


Two earlier volumes dedicated to the subject of obesity, published in the series “Advances in Biochemistry in Health and Disease” focused on the pathophysiology of obesity-induced health complications and the biochemistry of cardiovascular dysfunction in obesity. This book brings together contributions from international experts in the field to describe advancements on the mechanisms leading to development of obesity and related complications. There are 21 chapters in two different parts in this book, comprising of Part I: Pathophysiologic Mechanisms of Obesity (11 chapters) and Part II: Therapeutic Mechanisms of Obesity (10 chapters). 


This book will serve as a resource and be of interest to health professionals, medical students, fellows, residents and graduate students. It will also evoke innovative research and effective approaches for the prevention of obesity. This volume will accentuate that obesity is a major health hazard in its own right and that appropriate public health measures should be implemented to prevent or reduce or even reverse the impact of this global chronic disease.   

• INFLAMMATION
• CYTOKINES
• HORMONAL IMBALANCES
• AUTONOMIC NERVOUS SYSTEM
• OXIDATIVE STRESS

• St. Boniface Hospital Research, Asper Clinical Research Institute, Winnipeg, Canada

  Paramjit S. Tappia

• Asper Clinical Research Institute, St. Boniface Hospital, Winnipeg, Canada

  Bram Ramjiawan

• St. Boniface Hospital Research, Institute of Cardiovascular Science, Winnipeg, Canada

  Naranjan S. Dhalla

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