Overview
- Describes how to study the “functional” and the “non-functional” transcriptome
- Provides timely updates on advances in the field of transcriptomics in the six years since the first edition
- Addresses the role of transcriptomics in challenging groups of diseases and complex genetic diseases
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Table of contents (18 chapters)
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Front Matter
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Basic Principles of the Transcriptome and Its Analysis
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Front Matter
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Transcriptome in Disease
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Front Matter
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Keywords
About this book
The study of transcriptomics is key to understanding complex diseases. This new edition will build on the foundation of the first edition while incorporating the progress that has been made in the field of transcriptomics in the past six years, including bioinformatics for data analysis. Written by leading experts, chapters address new subjects such as methodological advances in large-scale sequencing, the sequencing of single-cells, and spatial transcriptomics. The new edition will address how transcriptomics may be used in combination with genetic strategies to identify causative genes in monogenic and complex genetic diseases. Coverage will also explore transcriptomics in challenging groups of diseases, such as cancer, inflammation, bacterial infection, and autoimmune diseases. The updated volume will be useful for geneticists, genome biologists, biomedical researchers, molecular biologists, bioinformaticians, and students, among others.
Editors and Affiliations
About the editor
Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. For several years, he worked in close collaboration with the microarray laboratory at Centre d´Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus. He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil) in which he is the coordinator of the Molecular Immunogenetics Group.
Bibliographic Information
Book Title: Transcriptomics in Health and Disease
Editors: Geraldo A. Passos
DOI: https://doi.org/10.1007/978-3-030-87821-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2022
Hardcover ISBN: 978-3-030-87820-7Published: 08 March 2022
eBook ISBN: 978-3-030-87821-4Published: 07 March 2022
Edition Number: 2
Number of Pages: XI, 474
Number of Illustrations: 5 b/w illustrations, 62 illustrations in colour
Topics: Genetics and Genomics, Biochemistry, general, Bioinformatics