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Antimalarial Natural Products

  • Book
  • © 2022

Overview

  • Provides comprehensive and up-to-date review on antimalarial natural products
  • Written by recognizes authorities in the field
  • Part of a well-known series

Part of the book series: Progress in the Chemistry of Organic Natural Products (POGRCHEM, volume 117)

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Table of contents (2 chapters)

Keywords

About this book

This volume begins with a short history of malaria and follows with a summary of its biology. It then traces the fascinating history of the discovery of quinine for malaria treatment, and then describes quinine’s biosynthesis, its mechanism of action, and its clinical use, concluding with a discussion of synthetic antimalarial agents based on quinine’s structure. It also covers the discovery of artemisinin and its development as the source of the most effective current antimalarial drug, including summaries of its synthesis and biosynthesis, its mechanism of action, and its clinical use and resistance. A short discussion of other clinically used antimalarial natural products leads to a detailed treatment of additional natural products with significant antiplasmodial activity, classified by compound type. Although the search for new antimalarial natural products from Nature’s combinatorial library is challenging, it is very likely to yield new antimalarial drugs. This book thus ends byidentifying ten natural products with development potential as clinical antimalarial agents.

Editors and Affiliations

  • College of Pharmacy, Ohio State University, Columbus, USA

    A. Douglas Kinghorn

  • Institute of Organic Chemistry, Johannes Kepler University, Linz, Austria

    Heinz Falk

  • School of Pharmacy, University of East Anglia, Norwich, UK

    Simon Gibbons

  • Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan

    Yoshinori Asakawa

  • School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China

    Ji-Kai Liu

  • Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria

    Verena M. Dirsch

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