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Combined Effects of Drugs and Toxic Agents

Modern Evaluation in Theory and Practice

  • Book
  • © 1993

Overview

Authors:
  1. Gerald Pöch

    1. Institut für Pharmakologie und Toxikologie, Universität Graz, Graz, Austria

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XI
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  2. Principle considerations of drug actions and interactions

    • Gerald Pöch
    Pages 1-14

  3. Concepts and models of interactions — additivity and independence

    • Gerald Pöch
    Pages 15-38

  4. Synergism/potentiation and antagonism — phenomena and mechanisms

    • Gerald Pöch
    Pages 39-53

  5. Evaluation by dose-response curves

    • Gerald Pöch
    Pages 54-66

  6. Evaluation by time-course studies

    • Gerald Pöch
    Pages 67-75

  7. Single-dose and other studies

    • Gerald Pöch
    Pages 76-82

  8. Combined-effect graph and other graphs

    • Gerald Pöch
    Pages 83-88

  9. Applications of the new approach and observations

    • Gerald Pöch
    Pages 89-116

  10. A new and critical view of isobolograms

    • Gerald Pöch
    Pages 117-121

  11. Comparison of the new with the conventional approach

    • Gerald Pöch
    Pages 122-129

  12. Epilog

    • Gerald Pöch
    Pages 130-131

  13. Back Matter

    Pages 132-167
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Keywords

About this book

Scientists struggling with the pharmaco- and toxicodynamic interactions of drugs and chemicals will find this book a valuable reference to the relevant theoretical background of this complex field and an indispensible guide to practical, analytical procedures for evaluation of experimental data. A new, straightforward mechanistically based analysis of observed combination effects is backed up by numerous examples as well as by computer-assisted plotting and curve fitting – using popular graphical software systems. The reader thus can gain not only a modern understanding of this complex area but proceed directly to the evaluation of his own dose-response experiments with respect to independent actions, and additive interactions, where appropriate. The meanings of terms and acronyms in the literature, most of them used in this book also, are elucidated by a comprehensive glossary. This book represents a modern, theoretical and practical guide for all scientists dealing with this controversial and complex area of the action and interaction of drugs and chemicals.

Authors and Affiliations

  • Institut für Pharmakologie und Toxikologie, Universität Graz, Graz, Austria

    Gerald Pöch

Bibliographic Information

  • Book Title: Combined Effects of Drugs and Toxic Agents

  • Book Subtitle: Modern Evaluation in Theory and Practice

  • Authors: Gerald Pöch

  • DOI: https://doi.org/10.1007/978-3-7091-9276-4

  • Publisher: Springer Vienna

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag/Wien 1993

  • Softcover ISBN: 978-3-211-82434-4Published: 16 March 1993

  • eBook ISBN: 978-3-7091-9276-4Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 167

  • Number of Illustrations: 53 b/w illustrations

  • Topics: Pharmacology/Toxicology, Anesthesiology, Endocrinology, Immunology, Virology, Oncology

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