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Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

  • Book
  • © 2015

Overview

Editors:
  1. Philip K. Moore

    1. National University of Singapore, Singapore, Singapore

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    You can also search for this editor in PubMed   Google Scholar

  2. Matt Whiteman

    1. ST. Luke's Campus, University of Exeter Medical School, Exeter, United Kingdom

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    You can also search for this editor in PubMed   Google Scholar

  • A recently discovered biological entity attracting growing interest from academics worldwide
  • Plays key roles in normal physiological processes whilst aberrant biosynthesis can lead, or contribute to, disease states
  • Growing impact within the pharmaceutical interest in drugs which manipulate its synthesis or activity
  • Includes supplementary material: sn.pub/extras

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 230)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-vi
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  2. Biochemistry, Molecular Biology and Chemistry

    1. Front Matter

      Pages 1-1
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    2. H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects

      • Caleb Weihao Huang, Philip Keith Moore
      Pages 3-25

  3. Molecular Mechanisms of Action

    1. Front Matter

      Pages 27-27
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    2. Persulfidation (S-sulfhydration) and H2S

      • Milos R. Filipovic
      Pages 29-59

    3. Physiological Roles of Hydrogen Sulfide and Polysulfides

      • Hideo Kimura
      Pages 61-81

  4. Cardiovascular and Urogenital Systems

    1. Front Matter

      Pages 83-83
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    2. H2S and Blood Vessels: An Overview

      • Guangdong Yang, Rui Wang
      Pages 85-110

    3. Hydrogen Sulfide and Urogenital Tract

      • Roberta d’Emmanuele di Villa Bianca, Giuseppe Cirino, Raffaella Sorrentino
      Pages 111-136

    4. H2S Is a Promoter of Angiogenesis: Identification of H2S “Receptors” and Its Molecular Switches in Vascular Endothelial Cells

      • Bei-Bei Tao, Wen-Jie Cai, Yi-Chun Zhu
      Pages 137-152

    5. Hydrogen Sulfide and Platelets: A Possible Role in Thrombosis

      • Michael Emerson
      Pages 153-162

  5. Inflammation and Inflammatory Disease

    1. Front Matter

      Pages 163-163
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    2. H2S and Inflammation: An Overview

      • Madhav Bhatia
      Pages 165-180

    3. Hydrogen Sulfide and Neuroinflammation

      • Kotaro Kida, Fumito Ichinose
      Pages 181-189

  6. H2S and the Nervous System

    1. Front Matter

      Pages 191-191
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    2. Brain, Learning, and Memory: Role of H2S in Neurodegenerative Diseases

      • B. V. Nagpure, Jin-Song Bian
      Pages 193-215

    3. H2S and Pain: A Novel Aspect for Processing of Somatic, Visceral and Neuropathic Pain Signals

      • Yuka Terada, Atsufumi Kawabata
      Pages 217-230

  7. H2S, Angiogenesis and Cancer

    1. Front Matter

      Pages 231-231
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    2. Hydrogen Sulfide and Cancer

      • Mark R. Hellmich, Csaba Szabo
      Pages 233-241

    3. Role of H2S Donors in Cancer Biology

      • Zheng-Wei Lee, Lih-Wen Deng
      Pages 243-265
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Keywords

About this book

This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

Editors and Affiliations

  • National University of Singapore, Singapore, Singapore

    Philip K. Moore

  • ST. Luke's Campus, University of Exeter Medical School, Exeter, United Kingdom

    Matt Whiteman

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