Authors:
Builds understanding of the immune system and its evolution
Provides a theoretical grounding in immunologic competence, for immunology and neurobiology
Improves epistemological awareness of disciplinary problems through the history of immunology
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Table of contents (5 chapters)
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Front Matter
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Back Matter
About this book
This book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals.
Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction.
A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters.
Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.
Authors and Affiliations
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Department of Basic Medical Sciences, Neurosciences, and Sensory Organs, University of Bari Medical School, Bari, Italy
Domenico Ribatti
Bibliographic Information
Book Title: The Development of Immunologic Competence
Authors: Domenico Ribatti
DOI: https://doi.org/10.1007/978-3-319-24663-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-24661-1Published: 09 March 2016
Softcover ISBN: 978-3-319-79655-0Published: 07 April 2018
eBook ISBN: 978-3-319-24663-5Published: 26 November 2015
Edition Number: 1
Number of Pages: VIII, 60
Number of Illustrations: 7 b/w illustrations, 22 illustrations in colour
Topics: Biomedicine general, Medicine/Public Health, general, Life Sciences, general