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Disordered Vertebral and Rib Morphology in Pudgy Mice

Structural Relationships to Human Congenital Scoliosis

  • Book
  • © 2016

Overview

Authors:
  1. Frederic Shapiro

    1. Department of Orthopedic Surgery, Children's Hospital Boston, Boston, USA

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  • Provides information on a structural study on vertebral abnormalities
  • Casts new light on human congenital scoliosis and spondylocostal dysplasia
  • Deals with all aspects of embryo and neonatal development in mouse, chicken and human vertebrate

Part of the book series: Advances in Anatomy, Embryology and Cell Biology (ADVSANAT, volume 221)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    • Frederic Shapiro
    Pages 1-2

  3. Materials and Methods

    • Frederic Shapiro
    Pages 3-6

  4. Results

    • Frederic Shapiro
    Pages 7-66

  5. Discussion

    • Frederic Shapiro
    Pages 67-109

  6. Conclusions

    • Frederic Shapiro
    Pages 111-113

  7. Back Matter

    Pages 115-123
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Keywords

About this book

​This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

Authors and Affiliations

  • Department of Orthopedic Surgery, Children's Hospital Boston, Boston, USA

    Frederic Shapiro

About the author

Frederic Shapiro received his MD degree from the University of Toronto Faculty of Medicine. He completed a residency in orthopedic surgery at the Montreal General Hospital: McGill University, Montreal, Quebec and a research fellowship in orthopedic surgery at Boston Children's Hospital.Frederic Shapiro, MD, Orthopedic Research Laboratory, Children's Hospital, Boston, USA.

Bibliographic Information

  • Book Title: Disordered Vertebral and Rib Morphology in Pudgy Mice

  • Book Subtitle: Structural Relationships to Human Congenital Scoliosis

  • Authors: Frederic Shapiro

  • Series Title: Advances in Anatomy, Embryology and Cell Biology

  • DOI: https://doi.org/10.1007/978-3-319-43151-2

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Softcover ISBN: 978-3-319-43149-9Published: 30 September 2016

  • eBook ISBN: 978-3-319-43151-2Published: 21 September 2016

  • Series ISSN: 0301-5556

  • Series E-ISSN: 2192-7065

  • Edition Number: 1

  • Number of Pages: IX, 123

  • Number of Illustrations: 5 b/w illustrations, 15 illustrations in colour

  • Topics: Human Genetics, Animal Anatomy / Morphology / Histology, Animal Models

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