Overview
- Doctoral thesis nominated as an outstanding PhD thesis by the University of Regensburg, Germany
- Describes novel sensors for obtaining dynamic cell response information
- Applies a variety of analytical methodology for multi-parametric monitoring of cell-based assays
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (7 chapters)
Keywords
- Cell-based assays
- Label-free high-content sensing
- Quartz crystal microbalance
- Impedance spectroscopy
- Electric cell-substrate impedance sensing
- Cytomechanic sensing
- Confocal laser scanning microscopy
- Optical temperature and oxygen imaging
- Dynamic cell response
- Biological recognition unit
- Mulitparametric whole-cell biosensing
- Fluorescence lifetime imaging
- Cell culture
About this book
The author, Maximilian Oberleitner, describes approaches in which the cells are directly grown on different sensor surfaces (gold-film electrodes, shear wave resonators or dye-doped polymer films). This approach, with the reacting cells in particularly close proximity and contact with the sensor surface, is key to a remarkable sensitivity, opening the way for a variety of new applications. This thesis not only introduces the fundamentals of each approach, but it also describes in great detail the design
principles and elucidates the boundary conditions of the new sensors.
Authors and Affiliations
About the author
Bibliographic Information
Book Title: Label-free and Multi-parametric Monitoring of Cell-based Assays with Substrate-embedded Sensors
Authors: Maximilian Oberleitner
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-45384-2
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2018
Hardcover ISBN: 978-3-319-45383-5Published: 05 October 2017
Softcover ISBN: 978-3-319-83279-1Published: 14 August 2018
eBook ISBN: 978-3-319-45384-2Published: 26 September 2017
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXVI, 370
Number of Illustrations: 16 b/w illustrations, 122 illustrations in colour
Topics: Analytical Chemistry, Nanochemistry, Laboratory Medicine, Cell Culture, Biological and Medical Physics, Biophysics