Non-canonical Cyclic Nucleotides

1. Front Matter

   Pages i-viii

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2. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions

   • Roland Seifert

   Pages 3-23

3. cCMP and cUMP in Apoptosis: Concepts and Methods

   • Sabine Wolter, Fanni Dittmar, Roland Seifert

   Pages 25-47

4. Mammalian Nucleotidyl Cyclases and Their Nucleotide Binding Sites

   • Stefan Dove

   Pages 49-66

5. The Pseudomonas aeruginosa Exoenzyme Y: A Promiscuous Nucleotidyl Cyclase Edema Factor and Virulence Determinant

   • K. Adam Morrow, Dara W. Frank, Ron Balczon, Troy Stevens

   Pages 67-85

6. Cyclic Nucleotide Monophosphates in Plants and Plant Signaling

   • Claudius Marondedze, Aloysius Wong, Ludivine Thomas, Helen Irving, Chris Gehring

   Pages 87-103

7. cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors

   • Robin Lorenz, Daniela Bertinetti, Friedrich W. Herberg

   Pages 105-122

8. Regulation of HCN Ion Channels by Non-canonical Cyclic Nucleotides

   • Bryan VanSchouwen, Giuseppe Melacini

   Pages 123-133

9. Interaction of Epac with Non-canonical Cyclic Nucleotides

   • Holger Rehmann

   Pages 135-147

10. Identification of cCMP and cUMP Substrate Proteins and Cross Talk Between cNMPs

    • Jens Schlossmann, Stefanie Wolfertstetter

    Pages 149-167

11. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport

    • Erich H. Schneider, Roland Seifert

    Pages 169-205

12. 3′,5′-cIMP as Potential Second Messenger in the Vascular Wall

    • Susan W. S. Leung, Yuansheng Gao, Paul M. Vanhoutte

    Pages 209-228

13. Discovery and Roles of 2′,3′-cAMP in Biological Systems

    • Edwin K. Jackson

    Pages 229-252

14. 8-Nitro-cGMP: A Novel Protein-Reactive cNMP and Its Emerging Roles in Autophagy

    • Hirokazu Arimoto, Daiki Takahashi

    Pages 253-268

15. Cyclic Dinucleotides in the Scope of the Mammalian Immune System

    • Arun K. Mankan, Martina Müller, Gregor Witte, Veit Hornung

    Pages 269-289

16. Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides

    • Heike Bähre, Volkhard Kaever

    Pages 293-306

17. Medicinal Chemistry of the Noncanonical Cyclic Nucleotides cCMP and cUMP

    • Frank Schwede, Andreas Rentsch, Hans-Gottfried Genieser

    Pages 307-337

18. Holistic Methods for the Analysis of cNMP Effects

    • Manuel Grundmann, Evi Kostenis

    Pages 339-357

19. The Chemistry of the Noncanonical Cyclic Dinucleotide 2′3′-cGAMP and Its Analogs

    • Frank Schwede, Hans-Gottfried Genieser, Andreas Rentsch

    Pages 359-384

20. Back Matter

    Pages 385-387

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The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.

• bacterial toxins
• cyclic nucleotides
• mass spectrometry
• nucleotidyl cyclases
• protein kinases
• signal transduction

• Medical School of Hannover Insitute of Pharmakology, Hannover, Germany

  Roland Seifert

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