Clinical Applications of Nuclear Medicine Targeted Therapy

1. Front Matter

   Pages i-xiv

   PDF

2. Thyroid Disease

   1. Front Matter

      Pages 1-1

      PDF

   2. Diagnosis and Treatment of Hyperthyroidism

      • Rosa Miranda Testa, Silvia Martinelli, Furio Pacini

      Pages 3-17

   3. Radiopharmaceuticals for Therapy of Thyroid Diseases

      • Katia Marzo

      Pages 19-23

   4. Radioiodine Therapy of Hyperthyroidism

      • Giovanna Pepe, Gennaro Cusato

      Pages 25-32

   5. Dosimetry in the Radioiodine Treatment of Hyperthyroidism

      • Cristina Canzi, Antonio Claudio Traino

      Pages 33-44

   6. New Approaches in the Management of Thyroid Cancer

      • Savvas Frangos, Ioannis Iakovou

      Pages 45-58

   7. Radioiodine Therapy of Thyroid Cancer

      • Ettore Seregni, Alice Lorenzoni, Laura Fugazzola

      Pages 59-68

   8. Radioiodine Therapy of Thyroid Cancer Dosimetry

      • Lorenzo Bianchi

      Pages 69-76

   9. Published Guidelines on Radioisotopic Treatments of Thyroid Diseases

      • Lucia Setti, Vicinelli Riccardo, Gianluigi Ciocia, Emilio Bombardieri, Laura Evangelista

      Pages 77-92

3. Hepatic Cancer

   1. Front Matter

      Pages 93-93

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   2. Clinical Options for Treatment of Hepatocellular Carcinoma

      • Matteo Virdis, Michela Monteleone, Michele Droz dit Busset, Vincenzo Mazzaferro

      Pages 95-105

   3. Medical Devices for Radioembolization

      • Anna Bogni, Claudio Pascali

      Pages 107-118

   4. HCC Radioembolization with Yttrium-90 Glass Microspheres (TheraSphere)

      • Marco Maccauro, Gianluca Aliberti, Carlo Chiesa, Carlo Spreafico

      Pages 119-125

   5. HCC Radioembolization with Yttrium-90 Polymer Beads (SIR-Spheres)

      • Marcello Rodari, Riccardo Muglia

      Pages 127-136

   6. Dosimetry in the Treatment of Liver Malignancies with Microspheres

      • Carlo Chiesa

      Pages 137-152

   7. The Clinical Challenge of Liver Metastasis

      • Stefano Cappato, Federica Brena, Michela Squadroni, Rosalba Barile, Davide Piccinali, Annalisa Mancin et al.

      Pages 153-163

   8. Radioembolization of Hepatic Metastases with 90Y-Microspheres: Indications and Procedure

      • Rosa Sciuto, Sandra Rea, Giuseppe Pizzi, Giulio E. Vallati, Lidia Strigari

      Pages 165-198

   9. Guidelines on Radioisotope Treatment of Liver Cancer and Liver Metastases with Intra-arterial Radioactive Compounds

      • Murat Fani Bozkurt, Laura Evangelista

      Pages 199-203

4. Neuroendocrine Tumors

   1. Front Matter

      Pages 205-205

      PDF

This book offers a practical and modern update on radioisotope therapy. Clinically oriented, it provides a thorough guide to patient management, with the latest indications and procedures for the current radioisotopic treatments. It addresses the clinical problems associated with each respective pathology, discussing the management of patients (diagnosis and non-radioisotope therapy), the radiopharmaceuticals available today, and the current radioisotopic procedures. Wherever possible, information on dosimetry is included at the end of each topic, together with a list of and comments on the most recent guidelines with their recommendations for radiometabolic therapy.

The book is divided into six main sections: thyroid diseases, hepatic tumors (HCC and hepatic metastases), bone metastases from prostate cancer, lymphomas, and neuroendocrine tumors. The last section is dedicated to new perspectives of radioisotope treatment. Based on contributions from of a multidisciplinary team of specialists: oncologists, surgeons, endocrinologists, hematologists, urologists, radiopharmacists and nuclear medicine physicians, it provides a comprehensive analysis of the position of radioisotope treatments among the various therapeutic options.

Readers interested in targeted therapy, radiometabolic therapy, radioimmunotherapy and radiometabolic imaging will find this book both informative and insightful.

• Radioisotope theraphy
• Targeted therapy
• Radiometabolic therapy
• Radiometabolic imaging
• Dosimetry
• Radioimmunotherapy
• Radiopharmaceuticals
• Radiaton Oncology

• Department of Nuclear Medicine, Humanitas Gavazzeni Hospital, Bergamo, Italy

  Emilio Bombardieri

• Nuclear Medicine Therapy and Endocrinology, Istituto Nazionale dei Tumori, Milano, Italy

  Ettore Seregni

• Nuclear Medicine and Molecular Imaging Unit, Veneto Institute of Oncology IOV - IRCCS, Padova, Italy

  Laura Evangelista

• Nuclear Medicine Division, Istituto Nazionale dei Tumori, Milano, Italy

  Carlo Chiesa

• Nuclear Medicine, Humanitas Research Hospital, Rozzano, Italy

  Arturo Chiti

Emilio Bombardieri graduated in Oncology and Nuclear Medicine at the University of Milan. In 1972 he joined the Istituto Nazionale Tumori, Milan, where he worked as a Nuclear Medicine Physician in the area of Oncology, Diagnosis and Therapy and later became Director of the Nuclear Medicine Division and Director of the Department of Diagnostic Imaging and Radiotherapy. In 2013 he was appointed

Scientific Director of Nuclear Medicine Division at Humanitas Gavazzeni Hospital and Coordinator of the Scientific Committee. Since 1982 he has been Professor of Physiology and Endocrinology at the Catholic University, ISEF, Milan. He served as President of the Italian Association of Nuclear Medicine (AIMN); he has chaired the EANM (European Association of Nuclear Medicine)Oncology Committee and was nominated President of the EANM Congress 2012 in Milan.

Ettore Seregni is the Head of the Nuclear Medicine Therapy and Endocrinology Unit atthe IRCCS National Cancer Institute of Milan. His current research interests include the development and clinical validation of different radiopharmaceuticals for cancer therapy. His main fields of clinical research are neuroendocrine tumors, prostatic and thyroid cancer, and metastatic bone lesions.

Laura Evangelista is a nuclear medicine physician working at Veneto Institute of Oncology IOV – IRCCS in Padova, Italy. She worked as a research fellow at University “Federico II” of Napoli Italy, Memorial Sloan Kettering of New York City, USA and th

e Mayo Clinic of Rochester (Minnesota, USA) focusing on PET/CT in breast cancer, prostate cancer and molecular imaging. In 2009 she joined the Veneto Institute of Oncology, where she is currently pursuing a special interest in the nuclear diagnostic evaluation of cancer.

Carlo Chiesa 

Since October 2005, member of Dosimetry Committee of the European Associationof Nuclear Medicine. Senior advisor member since 2013. From September 2006, coordinator of the of Italian Internal Dosimetry Group.
Teacher to IAEA dosimetry course in November 2013 & 2016, and EFOMP dosimetry course in 2016. In September 2016, IAEA expert mission to implement dosimetry in Kuwait City hospital.
From 2004 to the present, teacher of “Nuclear Medicine Equipment” at the postgraduate Nuclear Medicine School for physicians.
Consultant for Biocompatibles BTG L.t.d. for dosimetry and safety of Therasphere treatment of liver disease. In 2015, consultant of MedPace corelab (Cincinnati OHIO USA) for instrument validation in an international multicenter study.

Arturo Chiti graduated with a degree in Medicine and Surgery from the Univer

sity of Milan and joined the Training Program in Nuclear Medicine at the University of Milan. He subsequently worked as Associate Chief at the National Cancer Institute in Milan, where he beganhis clinic and scientific experience in Oncology. He was appointed Full Professor in Diagnostic Imaging and Radiotherapy at the Humanitas University in Milan and is currently Director of the Training Program in Diagnostic Imaging at Humanitas University. He served as President of the European Association of Nuclear Medicine and has advised the International Atomic Energy Agency for many years, and his contributions have been recognized with an honorary membership in the European Society for Therapeutic Radiology and Oncology.

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