Atlas of Ulcers in Systemic Sclerosis

1. Front Matter

   Pages i-xi

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2. Definition and Classification

   1. Front Matter

      Pages 1-1

      PDF

   2. Defining Digital Ulcers in Systemic Sclerosis: The State of the Art

      • Daniel E. Furst, Yossra Atef Suliman, Christopher P. Denton, Marco Matucci-Cerinic

      Pages 3-5

   3. Digital Ulcerations and Classification of SSc Subsets and Overlap Syndromes

      • Carina Gaertner, Oana-Diana Persa, Nicolas Hunzelmann

      Pages 7-13

   4. Classification of Digital and Lower Limb Ulcers in SSc

      • Jelena Blagojevic

      Pages 15-24

3. Pathobiology of Digital Ulcers

   1. Front Matter

      Pages 25-25

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   2. Vascular Mechanisms of Systemic Sclerosis

      • Janine Schniering, Britta Maurer, Oliver Distler

      Pages 27-37

   3. Introduction to Wound Healing and Tissue Repair

      • Sabine A. Eming

      Pages 39-41

4. Microvascular Modifications and Ulcers

   1. Front Matter

      Pages 43-43

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   2. Raynaud’s Phenomenon and Ulcers

      • Michael Hughes, Marina E. Anderson, Ariane L. Herrick

      Pages 45-62

   3. Capillary Microscopy

      • Maurizio Cutolo, Alberto Sulli, Vanessa Smith

      Pages 63-78

   4. Digital Ulcers, Vasculopathy and Internal Organ Involvement

      • Yannick Allanore

      Pages 79-85

5. Complications

   1. Front Matter

      Pages 87-87

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   2. Fistulas

      • Guya Piemonte, Francesca Braschi, Laura Rasero

      Pages 89-94

   3. Infections, Cellulitis, and Osteomyelitis

      • Silvia Bellando-Randone, Gemma Lepri

      Pages 95-98

   4. Digital Loss (Gangrene, Amputation, Autoamputation)

      • Jelena Blagojevic

      Pages 99-103

   5. Pain

      • Felice Galluccio

      Pages 105-107

   6. Clinical Impact of Digital Ulcers

      • Paul Legendre, Luc Mouthon

      Pages 109-113

   7. Calcinosis

      • Francesca Bartoli, Laura Cometi, Marco Matucci-Cerinic

      Pages 115-118

6. General Approach to Digital Ulceration: Algorithm

   1. Front Matter

      Pages 119-119

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This Atlas examines skin ulcers in patients affected by systemic sclerosis. Although they are not life threatening, digital ulcers cause enormous pain, impact function and quality of life, and can lead to serious local complications such as gangrene, osteomyelitis, and permanent tissue loss. Knowledge and understanding of these ulcers is pivotal in everyday practice in order to arrive at an accurate early diagnosis, a correct analysis of ulcer characteristics, and an appropriate direct and systematic treatment. To that end, this book describes all the major characteristics of skin ulcers in systematic sclerosis, including classification, evaluation, and categorization. Richly illustrated for practical use, Atlas of Ulcers in Systemic Sclerosis: Diagnosis and Management is an essential resource for physicians and related professionals, residents, and graduate students in rheumatology, dermatology, and angiology.

• Digital lesion
• Scleroderma
• Skin ulcer
• Systematic sclerosis
• ulcer

• Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy

  Marco Matucci-Cerinic

• Division of Medicine, University College London, Centre for Rheumatology, Royal Free Hospital, London, UK

  Christopher P. Denton

Marco Matucci-Cerinic, MD, PhD

Department of Experimental and Clinical Medicine

Division of Rheumatology AOUC

University of Florence

Florence, Italy

Christopher P. Denton, PhD, FRCP

UCL Division of Medicine

Centre for Rheumatology

Royal Free Hospital

London, England

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