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Statistical Methods in Toxicology

Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990

  • Conference proceedings
  • © 1991

Overview

Editors:
  1. Ludwig Hothorn

    1. Institute of Epidemiology and Biometry, German Cancer Research Center Heidelberg, Heidelberg, Germany

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Part of the book series: Lecture Notes in Medical Informatics (LNMED, volume 43)

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Table of contents (16 papers)

  1. Front Matter

    Pages N2-IV
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  2. Introduction

    1. Modern Statistical Methods in Toxicology — An overview

      • Ludwig Hothorn
      Pages 1-4

  3. Biostatistical Analysis of mutagenicity assays

    1. Statistical Analysis of the Ames Assay

      • Martin Schumacher, Claudia Schmoor
      Pages 5-19

    2. Statistical Analysis of the Micronucleus Test with the Fisher-Pitman Permutation Test

      • I. Leimer, H. Peil, J. Ellenberger
      Pages 20-24

    3. A Statistical Analysis of HGPRT-Test Data by Means of Computer Simulations

      • Stefan Rettig, Jürgen Lehn, Herbert G. Miltenburger
      Pages 25-34

    4. Measuring Intra-Assay Agreement for the Ames Salmonella Assay

      • Walter W. Piegorsch, Errol Zeiger
      Pages 35-41

    5. Tabular Overview of Statistical Methods Proposed for the Analysis of Ames Salmonella Assay Data

      • Joachim Vollmar, Lutz Edler
      Pages 42-48

  4. Biostatistical analysis of long-term carcinogenicity studies

    1. Analyses of Longterm Carcinogenicity Studies

      • Jörg Kaufmann
      Pages 49-64

    2. Mathematical models for the initiating and promotive action of carcinogens

      • Lars Ehrenberg, Gianpaolo Scalia-Tomba
      Pages 65-78

    3. Statistical Problems in Estimating a Threshold in a Dose-Response Model

      • Fredrik Granath
      Pages 79-85

  5. Biostatistical analysis of embryo-toxicity studies

    1. Per-Litter Analyses for Studies of Developmental Toxicity

      • Walter W. Piegorsch, Joseph K. Haseman
      Pages 86-95

    2. Biometrical Analysis of Strain Differences and Litter Effects

      • Reinhard Meister, Ibrahim Chahoud, Maike Jürgens, Frank Iversen, Gerd Bochert
      Pages 96-103

    3. Statistical Evaluation of Offspring Parameters in Embryotoxicity Studies

      • G. Rosenkranz, R. Uhl
      Pages 104-110

  7. Back Matter

    Pages 157-161
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Keywords

About this book

This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.

Editors and Affiliations

  • Institute of Epidemiology and Biometry, German Cancer Research Center Heidelberg, Heidelberg, Germany

    Ludwig Hothorn

Bibliographic Information

  • Book Title: Statistical Methods in Toxicology

  • Book Subtitle: Proceedings of a Workshop during EUROTOX ’90 Leipzig, Germany, September 12–14, 1990

  • Editors: Ludwig Hothorn

  • Series Title: Lecture Notes in Medical Informatics

  • DOI: https://doi.org/10.1007/978-3-642-48736-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-540-53621-5Published: 24 April 1991

  • eBook ISBN: 978-3-642-48736-1Published: 08 March 2013

  • Series ISSN: 0172-7788

  • Edition Number: 1

  • Number of Pages: IV, 161

  • Topics: Statistics for Life Sciences, Medicine, Health Sciences, Pharmacology/Toxicology

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