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  • © 2012

Antibiotic Resistance

  • This book provides views about antibiotic resistance from world experts in the field
  • The book has constructive ways in which to combat resistance,such as combinations of antibiotics, and targeting non-multiplying bacteria
  • It provides an outline of the challenges of the future, namely the need for a rebirth of the golden age of antibiotics in the mid-20th Century when 20 new classes of antibiotics reached the market

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 211)

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Table of contents (11 chapters)

About this book

This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.

Editors and Affiliations

  • , Div of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom

    Anthony R.M. Coates

Bibliographic Information

Buy it now

Buying options

eBook USD 349.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 449.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 449.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access