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Drug Toxicity in Embryonic Development I

Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk

  • Book
  • © 1997

Overview

Editors:
  1. Robert J. Kavlock

    1. Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. George P. Daston

    1. Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 124 / 1)

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Table of contents (20 chapters)

  1. Front Matter

    Pages I-XXVIII
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  2. Introduction

    1. Introduction

      • R. J. Kavlock, G. P. Daston
      Pages 1-7

  3. Recent Advances in Understanding Normal Development at the Biochemical and Molecular Level

    1. Front Matter

      Pages 9-9
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    2. Cardiac Morphogenesis: Formation and Septation of the Primary Heart Tube

      • R. Markwald, T. Trusk, A. Gittenberger-de Groot, R. Poelmann
      Pages 11-40

    3. Vertebrate Limb Development

      • K. Muneoka, R. Anderson
      Pages 41-75

    4. Axial Skeleton

      • A. Neubüser, R. Balling
      Pages 77-112

    5. Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System

      • J. D. Burrill, H. Saueressig, M. Goulding
      Pages 113-127

    6. Genetic Control of Kidney Morphogenesis

      • R. Maas, M. Rauchman
      Pages 129-182

    7. Palate

      • E. F. Zimmerman
      Pages 183-205

  4. Common Biochemical, Metabolic and Physiological Mechanism of Abnormal Development

    1. Front Matter

      Pages 209-209
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    2. Cell Death

      • T. B. Knudsen
      Pages 211-244

    3. Cellular Responses to Stress

      • P. E. Mirkes
      Pages 245-275

    4. Cell-Cell Interactions

      • P. J. Linser
      Pages 277-300

    5. Growth Factor Disturbance

      • G. T. O’Neill, R. J. Akhurst
      Pages 301-324

    6. Targeted Gene Disruptions as Models of Abnormal Development

      • T. W. Sadler, E. T. Liu, K. A. Augustine
      Pages 325-337

    7. Nucleotide Pool Imbalance

      • C. Lau
      Pages 341-372

    8. Interference with Embryonic Intermediary Metabolism

      • E. S. Hunter III
      Pages 373-406

    9. Alterations in Folate Metabolism as a Possible Mechanism of Embryotoxicity

      • D. K. Hansen
      Pages 407-432

    10. Prostaglandin Metabolism

      • M. P. Goto, A. S. Goldman
      Pages 433-452

    11. Reactive Intermediates

      • P. G. Wells, P. M. Kim, C. J. Nicol, T. Parman, L. M. Winn
      Pages 453-518
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Keywords

About this book

Having received the invitation from Springer-Verlag to produce a volume on drug-induced birth defects for the Handbook of Experimental Pharmacology, we asked ourselves what new approach could we offer that would capture the state of the science and bring a new synthesis of the information on this topic to the world's literature. We chose a three-pronged approach, centered around those particular drugs for which we have a relatively well established basis for understanding how they exert their unwanted effects on the human embryo. We then supplemented this information with a series of reviews of critical biological processes involved in the established normal developmental patterns, with emphasis on what happens to the embryo when the processes are perturbed by experimental means. Knowing that the search for mechanisms in teratology has often been inhibited by the lack of understanding of how normal development proceeds, we also included chapters describing the amazing new discoveries related to the molecular control of normal morphogenesis for several organ systems in the hope that the experimental toxicologists and molecular biologists will begin to better appreciate each others questions and progress. Several times during the last two years of developing outlines, issuing invitations, reviewing chapters, and cajoling belated contributors, we have wondered whether we made the correct decision to undertake this effort.

Editors and Affiliations

  • Reproductive Toxicology Division (MD-71), National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, USA

    Robert J. Kavlock

  • Miami Valley Laboratories, The Procter and Gamble Company, Cincinnati, USA

    George P. Daston

Bibliographic Information

  • Book Title: Drug Toxicity in Embryonic Development I

  • Book Subtitle: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk

  • Editors: Robert J. Kavlock, George P. Daston

  • Series Title: Handbook of Experimental Pharmacology

  • DOI: https://doi.org/10.1007/978-3-642-60445-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1997

  • Softcover ISBN: 978-3-642-64408-5Published: 28 January 2012

  • eBook ISBN: 978-3-642-60445-4Published: 06 December 2012

  • Series ISSN: 0171-2004

  • Series E-ISSN: 1865-0325

  • Edition Number: 1

  • Number of Pages: XXVIII, 610

  • Number of Illustrations: 1 illustrations in colour

  • Topics: Pharmacology/Toxicology, Cell Biology, Human Physiology, Biochemistry, general, Obstetrics/Perinatology/Midwifery

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