Pharmacology of the Eye

1. Front Matter

   Pages I-XXV

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2. The History of Ophthalmic Therapeutics

   • M.-H. Heinemann

   Pages 1-17

3. Ocular Pharmacokinetics

   • D. M. Maurice, S. Mishima

   Pages 19-116

4. Biotransformation and Drug Metabolism

   • H. Shichi

   Pages 117-148

5. Cholinergics

   • P. L. Kaufman, T. Wiedman, J. R. Robinson

   Pages 149-191

6. Autonomic Nervous System: Adrenergic Agonists

   • M. L. Sears

   Pages 193-248

7. Autonomic Nervous System: Adrenergic Antagonists

   • V. J. Lotti, J. C. LeDouarec, C. A. Stone

   Pages 249-277

8. Carbonic Anhydrase: Pharmacology of Inhibitors and Treatment of Glaucoma

   • B. R. Friedland, T. H. Maren

   Pages 279-309

9. Autacoids and Neuropeptides

   • J. Stjernschantz

   Pages 311-365

10. Vitamin A

    • G. J. Chader

    Pages 367-384

11. Anti-Infective Agents

    • I. H. Leopold

    Pages 385-457

12. Anti-Inflammatory Agents

    • J. R. Polansky, R. N. Weinreb

    Pages 459-538

13. Anti-Inflammatory Agents: Nonsteroidal Anti-Inflammatory Drugs

    • K. Masuda

    Pages 539-551

14. Chemotherapy of Ocular Viral Infections and Tumors

    • P. H. Fischer, W. H. Prusoff

    Pages 553-583

15. Immunosuppressive Drugs

    • I. Gery, R. B. Nussenblatt

    Pages 585-609

16. Anticoagulants, Fibrinolytics, and Hemostatics

    • M. Pandolfi

    Pages 611-626

17. Oxygen

    • R. W. Flower, M. O. Hall

    Pages 627-638

18. The Aliphatic Alcohols

    • A. M. Potts

    Pages 639-653

19. Photosensitizing Substances

    • A. M. Potts

    Pages 655-666

20. Trace Elements in the Eye

    • T. R. Jones, T. W. Reid

    Pages 667-685

Roots of the theory and practice of ocular pharmacology may be traced to the ancient Mesopotamian code of Hammurabi and then to several papyri reflecting the clinical interests of the Egyptians. The evolution of its art and science was irregularly paced until the nineteenth century when Kohler, in 1884, proved the anesthetic effect of cocaine on the cornea, and when Fraser, Laquer, Schmiedeberg, Meyer, and others studied the pharmacology of the autonomic nervous system by way of observations of the pupil. Advances in the past few decades have been nothing short of explosive. How can the student, physician, or basic research scientist stay in touch with these electrifying studies? To help with the answer to this question, the authors set as their goal the development of increased understanding so that the student, research scientist, and ophthalmologist can cope with the latest discoveries. The authors want to narrow what appears to be an ever-increasing gap between basic science and ophthalmology. The basic aspects of pharmacology have been presented in light of the natural physiology. In this regard, while distinctions among endogenous mechanisms, drug effects, and the pathogenesis of disease are to be separately recognized, appreciation must be given to the concept that both the desirable and unwanted manifestations or functions caused by either disease or drugs must very often represent a quantitative change in normal metabolic pathways.

• Ophthalmikum
• cocaine
• drug
• eye
• pathogenesis
• pharmacology
• physiology
• research

• Department of Ophthalmology and Visual Science, School of Medicine, Yale University, New Haven, USA

  Marvin L. Sears

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