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Anxiolytic β-Carbolines

From Molecular Biology to the Clinic

  • Book
  • © 1993

Overview

Editors:
  1. David N. Stephens

    1. Neuropsychopharmacology, Schering AG, Berlin, Germany

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Part of the book series: Psychopharmacology Series (PSYCHOPHARM, volume 11)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XI
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  2. Discovery of β-Carboline Ligands for Benzodiazepine Receptors

    • C. Braestrup, M. Nielsen
    Pages 1-6

  3. β-Carboline-3-Carboxylic Acid Ethyl Ester: a Lead for New Psychotropic Drugs

    • R. Schmiechen, D. Seidelmann, A. Huth
    Pages 7-15

  4. Molecular Biology of Gamma-Aminobutyric Acid Type A/Benzodiazepine Receptors

    • H. Lüddens
    Pages 16-28

  5. Immunohistochemical Mapping of Gamma-Aminobutyric Acid Type-A Receptor Alpha Subunits in Rat Central Nervous System

    • J. D. Turner, G. Bodewitz, C. L. Thompson, F. A. Stephenson
    Pages 29-49

  6. Abecarnil is a Full Agonist at Some, and a Partial Agonist at Other Recombinant GABAA Receptor Subtypes

    • I. Pribilla, R. Neuhaus, R. Huba, M. Hillmann, J. D. Turner, D. N. Stephens et al.
    Pages 50-61

  7. Pharmacological Evidence for Full Agonist Activity of Abecarnil at Certain GABAA Receptors

    • M. Serra, C. A. Ghiani, C. Motzo, G. Biggio
    Pages 62-78

  8. Abecarnil: A Novel Anxiolytic with Mixed Full Agonist/Partial Agonist Properties in Animal Models of Anxiety and Sedation

    • D. N. Stephens, L. Turski, G. H. Jones, K. G. Steppuhn, H. H. Schneider
    Pages 79-95

  9. Abecarnil Shows Reduced Tolerance Development and Dependence Potential in Comparison to Diazepam: Animal Studies

    • W. Löscher
    Pages 96-112

  10. Behavioral Pharmacology of Abecarnil in Baboons: Reduced Dependence and Abuse Potential

    • C. A. Sannerud, N. A. Ator, R. R. Griffiths
    Pages 113-120

  11. Abecarnil Used to Treat Benzodiazepine Withdrawal

    • M. W. Emmett-Oglesby, D. A. Lytle, S. A. English
    Pages 121-131

  12. Abecarnil: A New ß-Carboline Anxiolytic Preliminary Clinical Pharmacology

    • T. Duka, W. Krause, R. Dorow, A. Rohloff, H. Ott, B. Voet
    Pages 132-147

  13. Back Matter

    Pages 149-151
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Keywords

About this book

Since the discovery some 15 years ago of benzodiazepine modulatory sites associated with GABA A receptors, great effort has gone into understanding their molecular pharmacology and into developing new anxiolytic drugs that interact selectively with them. Prominent in this research has beenthe discovery that ~-carbolines, a different chemical class from benzodiazepines, also act at these receptors but that their effects are sometimes quite different from those of the benzodiazepines.This book documents the latest discoveries in the molecular biology of the GABA A receptor and reveals how an integration of the results of research inmolecular biology, synthetic chemistry, biochemical and behavioral pharmacology, and clinical pharmacology has paved the way forthe development of ~-carbolines from substances inducing anxiety and convulsions to a novel therapy for anxiety states, achieving a behavioral selectivity through selective actions at subtypes of receptors.

Editors and Affiliations

  • Neuropsychopharmacology, Schering AG, Berlin, Germany

    David N. Stephens

Bibliographic Information

  • Book Title: Anxiolytic β-Carbolines

  • Book Subtitle: From Molecular Biology to the Clinic

  • Editors: David N. Stephens

  • Series Title: Psychopharmacology Series

  • DOI: https://doi.org/10.1007/978-3-642-78451-4

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1993

  • Softcover ISBN: 978-3-642-78453-8Published: 08 December 2011

  • eBook ISBN: 978-3-642-78451-4Published: 07 March 2013

  • Series ISSN: 0931-6795

  • Edition Number: 1

  • Number of Pages: XI, 151

  • Number of Illustrations: 9 illustrations in colour

  • Topics: Pharmacology/Toxicology, Psychiatry

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