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Intracellular Regulation of Ion Channels

  • Conference proceedings
  • © 1992

Overview

Editors:
  1. Martin Morad

    1. School of Medicine, Dept. of Physiology, University of Pennsylvania, Philadelphia, USA

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  2. Zalman Agus

    1. School of Medicine, Dept. of Physiology, University of Pennsylvania, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nato ASI Subseries H: (ASIH, volume 60)

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Table of contents (26 papers)

  1. Front Matter

    Pages I-X
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  2. Regulation of K+ Channels

    1. Front Matter

      Pages 1-1
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    2. K+ Channel Diversity

      • O. Pongs
      Pages 3-8

    3. Regulation of Voltage-Activated K+ Channels

      • Arthur M. Brown
      Pages 9-13

    4. Gating Mechanisms of Shaker Potassium Channels

      • R. Aldrich
      Pages 15-20

    5. Vaccinia Virus: A Novel Expression System for Receptors and Ion Channels

      • Andreas Karschin
      Pages 21-25

    6. Delayed Rectification in the Heart: Regulation and Physiology

      • W. M. Kwok, L. C. Freeman, J. Anumonwo, R. S. Kass
      Pages 27-42

    7. Receptor-Dependent Modulation of G Protein-Gated Muscarinic K+ Channel by Arachidonic Acid Metabolites

      • Yoshihisa Kurachi
      Pages 43-52

    8. The Na+-Activated K+ Channel in Cardiac Cells

      • E. Carmeliet, H.-N. Luk
      Pages 53-59

    9. Regulation of the ATP-Dependent K+ Channel of Muscle by ATP and pH

      • N. B. Standen, N. W. Davies, A. Pettit, P. R. Stanfield
      Pages 61-69

    10. Regulation of Cardiac ATP-Sensitive K+ Channels

      • James N. Weiss, Nagammal Venkatesh, Nicholas A. Deutsch
      Pages 71-81

    11. ATP-Sensitive K+ Channels : Molecular Pharmacology, Regulation and Role in Diseased States

      • M. Lazdunski, M. Fosset, J. De Weille, E. Honoré, C. Mourre
      Pages 83-86

  3. Regulation of Ca2+ Channels

    1. Front Matter

      Pages 87-87
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    2. Tissue distribution and possible function of the subunits of the L-type calcium channels

      • F. Hofmann, M. Biel, R. Hullin, E. Bosse, V. Flockerzi
      Pages 89-97

    3. Phosphorylation and Regulation of Calcium Channels by Multiple Protein Kinases

      • M. Marlene Hosey, Rebecca M. Brawley, Chan Fong Chang, Luis Miguel Gutierrez, Cecilia Mundina-Weilenmann, Jianjie Ma et al.
      Pages 99-106

    4. Action of the GTP-binding protein Gs on cardiac Ca++ channels

      • A. Cavalié, T. J. A. Allen, W. Trautwein
      Pages 107-112

    5. Membrane-Delimited Stimulation of Heart Cell Calcium Current by ß-Adrenergic Signal-Transducing Gs Protein

      • S. Pelzer, Y. M. Shuba, L. Birnbaumer, T. F. McDonald, D. J. Pelzer
      Pages 113-127

    6. Participation of a Fast G Protein Pathway in the ß-Adrenergic Regulation of Cardiac Calcium Channels: Neither Proven nor Needed

      • R. Fischmeister, P.-F. Méry, H. C. Hartzell, G. Szabo
      Pages 129-139

    7. Kinetics of a G-Protein Mediated Action on Neuronal Ca2+ Channels

      • H. D. Lux, N. Tokutomi, F. Grassi
      Pages 141-151

    8. Identification of G-Proteins Involved in the Inhibition of Ca2+ Currents in Neuronal and Endocrine Cells

      • J. Hescheler, C. Kleuss, C. Ewel, B. Wittig, W. Rosenthal, G. Schultz
      Pages 153-159
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Keywords

About this book

Understanding the molecular processes by which ionic channels are regulated is central to the understanding of cellular function. Great advances in understanding these regulatory mechanisms have been recently achieved by the combination of several powerful techniques. Development of the patch clamp technique, ability to access the intracellular channels sites, and genetic manipulation of channel structure have allowed studies of channel function in native membranes. Cloning, sequencing and determining the channel structure and its subunits allows further insight into the regulatory mechanisms of channel function. In planning this symposium, we organized the scientific discussions around specific molecular topics independent of the tissue and species of origin. Clearly, the subject of ion channel regulation is multi-faceted, with a large number of very talented scientists working in the field. The NATO Symposium represented an attempt to bring together these individuals and synthesize and evaluate new ideas and experimental findings. A great deal of novel data was presented, and scientific insight into the molecular processes which regulate ionic channels was furthered. This book gives a synopsis of the scientific presentations and is organized into 3 sections. The first section deals with the diversity of K + channels and their regulation, including structure-function and mechanistic studies. Presentations dealt with the characterization and modulation of a variety ofK+ channels in cardiac and neuronal cells, including ATP­ dependent K+ channels, Na + -activated K+ channels, delayed rectifier K+ channels and the diversity of their regulation by G-proteins.

Editors and Affiliations

  • School of Medicine, Dept. of Physiology, University of Pennsylvania, Philadelphia, USA

    Martin Morad, Zalman Agus

Bibliographic Information

  • Book Title: Intracellular Regulation of Ion Channels

  • Editors: Martin Morad, Zalman Agus

  • Series Title: Nato ASI Subseries H:

  • DOI: https://doi.org/10.1007/978-3-642-84628-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1992

  • Softcover ISBN: 978-3-642-84630-4Published: 15 December 2011

  • eBook ISBN: 978-3-642-84628-1Published: 29 June 2013

  • Series ISSN: 1010-8793

  • Edition Number: 1

  • Number of Pages: X, 251

  • Topics: Biochemistry, general, Zoology, Pharmacology/Toxicology, Neurosciences

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