Stem Cells from Cord Blood, in Utero Stem Cell Development and Transplantation-Inclusive Gene Therapy

1. Front Matter

   Pages I-XIX

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2. Plasticity of Stem Cells

   • U. Kapp, R. Mertelsmann

   Pages 1-17

3. Lentiviral Vectors for the Genetic Modification of Hematopoietic Stem Cells

   • D. Trono

   Pages 19-28

4. Origin and Developmental Plasticity of Haematopoietic Stem Cells

   • A. M. Müller, H. Geiger, G. Eichholz, F. Harder

   Pages 29-46

5. The New York Blood Center’s Placental/Umbilical Cord Blood Program. Experience with a ‘New’ Source of Hematopoietic Stem Cells for Transplantation

   • P. Rubinstein, C. E. Stevens

   Pages 47-70

6. Chances and Limits of Cord Blood Transplantation

   • E. Wunder

   Pages 71-83

7. Legal and Ethical Issues Involved in Cord Blood Transplantation and Banking

   • K. Seelmann

   Pages 85-98

8. Fetal Somatic Gene Therapy — A Preventive Approach to the Treatment of Genetic Disease: The Case For

   • C. Coutelle, M. Themis, H. Schneider, T. Kiserud, T. Cook, A.-M. Douar et al.

   Pages 99-114

9. Prenatal Transplantation of Hematopoietic Stem Cells: Overview

   • D. V. Surbek, W. Holzgreve

   Pages 115-122

10. Fetal Hematopoietic Stem Cells: In Vitro Expansion and Transduction Using Lentiviral Vectors

    • A. Luther-Wyrsch, C. Nissen, D. V. Surbek, W. Holzgreve, E. Costello, M. Thali et al.

    Pages 123-144

11. Tolerance Induction Post In Utero Stem Cell Transplantation

    • M. J. Cowan, S.-H. Chou, A. F. Tarantal

    Pages 145-171

12. Fetal Hematopoiesis During First and Second Trimester of Pregnancy: Relevance for In Utero Stem Cell Transplantation

    • J. Wilpshaar, H. H. H. Kanhai, S. Scherjon, J. H. F. Falkenburg

    Pages 173-186

13. Tolerance Induction Following In Utero Stem Cell Transplantation

    • D. R. E. Jones, E. M. Anderson, D. T. Y. Liu, R. M. Walker

    Pages 187-196

14. In Utero Stem Cell Transplantation in Humans

    • M. Westgren, L. E. Shields

    Pages 197-221

15. Back Matter

    Pages 223-229

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The title "Stem Cells from Cord Blood, In Utero Stem Cell Develop­ ment, and Transplantation-Inclusive Gene Therapy" suggests that more than one topic is combined in one workshop. Indeed, at first glance the recovery of stem cells from cord blood has to be seen as separate from the attempts to achieve effective in utero therapy by stem cell trans­ plantation, because the first issue deals with an innovative stem cell source as an alternative to bone marrow, which is already spreading rapidly in medical practice, whereas the second topic is still strictly ex­ perimental and only investigated in medical centers with the appropri­ ate background. It is, however, not only justified, but helpful to com­ bine the two topics in one workshop and consequently to cover them in the same volume of the Ernst Schering Research Foundation Work­ shop series, because they are intimately related and both based on the new insights into the biology of stem cells. Professor Werner Arber, the Nobel Laureate from the University of Basel, pointed out in his In- Professor Dr. W. Holzgreve VI Preface The participants of the workshop troductory Lecture that our understanding of hematopoietic stem cells as descendents of totipotent cells and our current approaches to using them in post-and prenatal therapy have been furthered significantly by genetic engineering technologies which are "artificial contributions to the process of biologic evolution".

• Hematopoietic stem cells (HSC)
• blood
• bone marrow
• cell
• cell therapy
• gene
• gene therapy
• hematopoietic stem cell
• metabolism
• placenta
• pregnancy
• stem cell
• stem cell transplantation
• stem cells
• transplantation

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