Metronomic Chemotherapy

1. Front Matter

   Pages i-xvi

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2. Pharmacological Bases of Metronomic Chemotherapy

   1. Front Matter

      Pages 1-1

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   2. Development and Evolution of the Concept of Metronomic Chemotherapy: A Personal Perspective

      • Robert S. Kerbel

      Pages 3-21

   3. Mechanisms of Action of Low-Dose Metronomic Chemotherapy

      • Ella Fremder, Yuval Shaked

      Pages 23-38

   4. Effects of Metronomic Chemotherapy on Immunity

      • Mamoru Harada

      Pages 39-51

   5. Preclinical Activity of Metronomic Regimens with Alkylating Agents and Antimetabolites

      • Marta Vives, Berta Laquente, Francesc Viñals

      Pages 53-67

   6. Metronomic Chemotherapy Regimens Using Microtubule-Targeting Agents: Mechanisms of Action, Preclinical Activity and Future Developments

      • Eddy Pasquier, Maria Kavallaris, Nicolas Andre

      Pages 69-90

3. Clinical Activity of Metronomic Chemotherapy

   1. Front Matter

      Pages 91-91

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   2. Metronomic Chemotherapy in Breast Cancers

      • Elisabetta Munzone, Francesco Bertolini, Marco Colleoni

      Pages 93-110

   3. Overview of Metronomic Chemotherapy in SWOG Breast Cancer Cooperative Group Clinical Trials

      • Zeina A. Nahleh

      Pages 111-118

   4. Clinical Trials of Low-Dose Metronomic Chemotherapy in Castration-Resistant Prostate Cancer

      • Keemo Delos Santos, Lavarnan Sivanathan, Kelly Lien, Urban Emmenegger

      Pages 119-134

   5. The Role of Metronomic Chemotherapy in the Treatment of Metastatic Colorectal Cancer Patients

      • Lisa Salvatore, Federica Zoratto, Fotios Loupakis, Alfredo Falcone

      Pages 135-142

   6. Clinical Activity of Metronomic Chemotherapy in Central Nervous System Cancers

      • Doo-Sik Kong, Do-Hyun Nam

      Pages 143-155

   7. Metronomic Chemotherapy in Pediatric Malignancies

      • Narges Baluch, Sushil Kumar, Reza Mokhtari, Sylvain Baruchel

      Pages 157-172

   8. Metronomic Chemotherapy in Hematological Malignancies

      • Pannee Praditsuktavorn, Jia Ruan

      Pages 173-188

   9. Clinical Activity of Metronomic Chemotherapy in Liver Cancers

      • Yu-Yun Shao, Ann-Lii Cheng, Chih-Hung Hsu

      Pages 189-202

   10. Metronomic Chemotherapy in Gynecological Cancers

       • Victoria A. Forte, Agustin A. Garcia

       Pages 203-216

   11. Metronomic Chemotherapy in Non-Small-Cell Lung Cancer

       • Athanasios Kotsakis, Nikolaos Kentepozidis, Vassilis Georgoulias

       Pages 217-226

4. Clinical Pharmacology of Metronomic Chemotherapy

   1. Front Matter

      Pages 227-227

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   2. Pharmacokinetics and Pharmacogenetics of Metronomic Chemotherapy

      • Guido Bocci, Giulio Francia

      Pages 229-246

This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.

• Antiangiogenic drugs
• Cancer
• Metronomic chemotherapy
• Pharmacology

• Division of Pharmacology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

  Guido Bocci

• Department of Biological Sciences, University of Texas at El Paso, El Paso, USA

  Giulio Francia

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