Vascular Engineering

1. Front Matter

   Pages i-vi

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2. Introduction

   • Kazuo Tanishita, Kimiko Yamamoto

   Pages 1-11

3. Fundamentals of Vascular Bio-fluid and Solid Mechanics

   • Masako Sugihara-Seki, Hiroshi Yamada

   Pages 13-45

4. Fundamentals of Physiology and Biology of Vascular System

   • Tomohiro Aoki, Kimiko Yamamoto

   Pages 47-68

5. Hemodynamics in Physio- and Pathological Vessels

   • Shigeru Tada, John M. Tarbell

   Pages 69-98

6. Cyclic Stretch-Induced Reorganization of Stress Fibers in Endothelial Cells

   • Roland Kaunas, Shinji Deguchi

   Pages 99-110

7. Mechanical Characterization of Vascular Endothelial Cells Exposed to Fluid Shear Stress

   • Toshiro Ohashi

   Pages 111-126

8. Tensile Properties of Smooth Muscle Cells, Elastin, and Collagen Fibers

   • Takeo Matsumoto, Shukei Sugita, Kazuaki Nagayama

   Pages 127-140

9. Mechanobiology of Endothelial Cells Related to the Formation of Arterial Disease

   • Noriyuki Kataoka

   Pages 141-157

10. Mechanotransduction of Shear Stress by the Endothelium

    • Peter J. Butler

    Pages 159-197

11. Mechanobiology of Endothelial Cells Related to the Pathogenesis of Arterial Disease

    • Susumu Kudo

    Pages 199-209

12. Vascular Engineering of Blood Coagulation

    • Shinya Goto

    Pages 211-219

13. Vascular Engineering to Make Blood-Compatible Surface

    • Hiroshi Ujiie, Yoshiaki Suzuki, Dieter Liepsch

    Pages 221-230

14. Vascular Engineering of Circulatory Assist Devices

    • Masahiro Nishida

    Pages 231-266

15. Innovations in Measuring Cellular Mechanics

    • Navid Bonakdar, Achim Schilling, Richard Gerum, José Luis Alonso, Wolfgang H. Goldmann

    Pages 267-281

16. Innovation of Vascular Engineering by Mechanomedicine

    • Ken Takahashi, Keiji Naruse

    Pages 283-296

17. Integrated Vascular Engineering: Vascularization of Reconstructed Tissue

    • Ryo Sudo, Seok Chung, Yoojin Shin, Kazuo Tanishita

    Pages 297-332

18. Novel Technology to Assay the Multicellular Network: On-Chip Cellomics Technology

    • Kenji Yasuda

    Pages 333-393

19. Back Matter

    Pages 395-401

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This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. 


As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.

• atherosclerosis
• biomaterials
• endothelium
• hemodynamics
• regeneration
• vascularization

• Waseda University, Tokyo, Japan

  Kazuo Tanishita

• The University of Tokyo, Tokyo, Japan

  Kimiko Yamamoto

KazuoTanishita: Waseda University Research Organization for Nano & Life Innovation
Kimiko Yamamoto: Department of Biomedical Engineering, The University of Tokyo

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